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Aureobasidium pullulansの産生するβ-1.3-1.6グルカンによって培養されたヒト末梢血単核球の免疫応答
https://doi.org/10.15069/00000594
https://doi.org/10.15069/0000059443c19a43-a32c-42db-9773-9f6b03182c26
名前 / ファイル | ライセンス | アクション |
---|---|---|
KJ00004191074 (618.4 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2005-03-25 | |||||
タイトル | ||||||
タイトル | Aureobasidium pullulansの産生するβ-1.3-1.6グルカンによって培養されたヒト末梢血単核球の免疫応答 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Immunological respnses of human peripheral blood mononuclear cells (PBMCs) derived from healthy donors cultured with β-1.3-1.6 glucan produced by Aureobasidium pullulans | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aureobasidium pullulans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | β-1.3-1.6 glucan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD11a | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 細胞増殖 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-8 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ヒト末梢血単核球 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Aureobasidium pullulans | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | β-1.3-1.6 glucan | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CD11a | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cell proliferation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | IL-8 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | PBMCs | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15069/00000594 | |||||
ID登録タイプ | JaLC | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
記事種別(日) | ||||||
値 | 保健科学部 | |||||
記事種別(英) | ||||||
言語 | en | |||||
値 | School of Health Science | |||||
著者名(日) |
池脇, 信直
× 池脇, 信直× 藤井, 昇× 尾仲, 隆× 山尾, 裕道× 井上, 博 |
|||||
著者名よみ |
イケワキ, ノブナオ
× イケワキ, ノブナオ× フジイ, ノボル× オナカ, タカシ× ヤマオ, ヒロミチ× イノウエ, ヒロシ |
|||||
著者名(英) |
IKEWAKI, Nobunao
× IKEWAKI, Nobunao× FUJII, Noboru× ONAKA, Takashi× YAMAO, Hiromichi× INOUE, Hiroshi |
|||||
著者所属(日) | ||||||
値 | 九州保健福祉大学保健科学部作業療法科 : 免疫研究所 | |||||
著者所属(日) | ||||||
値 | 聖心ウルスラ学園短期大学 | |||||
著者所属(日) | ||||||
値 | ソフィ株式会社 | |||||
著者所属(日) | ||||||
値 | 井上病院 | |||||
著者所属(日) | ||||||
値 | 井上病院 | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Occupational Therapy, School of Health Science, Kyushu University of Health and Welfar : Institute of Immunology | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Seishin Ursura Gakuen Mission Junior College | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Sophy Corporation | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Inoue Hospital | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Inoue Hospital | |||||
抄録(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Aureobasidium pullulansによって産生されるβ-1.3-1.6グルカンは、ヒト末梢血単核球のトリチウムサイミジンの取り込み(細胞増殖)を優位に増強させた。この細胞増殖の増強は、CD11a(lymphocyte-function associated antigen-1: LFA-1)に対するモノクローナル抗体(mNI-58A)で完全に抑制された。さらに、β-1.3-1.6グルカンはヒト末梢血単核球ののインターロイキン-8(IL-8)産生能も有意に増加された。以上の結果は、β-1.3-1.6グルカンがLFA-1(CD11a)分子の経路を介してヒト末梢血単核球に免疫能を付与したことを示すものである。 | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | We have succeed in purifying a new β-1.3-1.6 gluchan produced by the black yeast Aureobasidium pullulans (A, pullulnas) FO68, and reported that this β-1.3-1.6 glucan has unique immunological actions such as interleukin-8 (IK-8) production in the human monocyte-like cell line U937 and the acquistion of natural killer (NK) activity in mouse peritoneal cells. In this study, we investigated some immunological responses of the β-1.3-1.6 glucan on human peripheral blood mononuclear cells (PBMCs) derived from healthy donors. The ^3H-thymidine incorporation rates (cell proliferation) of the human PBMCs cultured with β-1.3-1.6 glucan were significnatly enhanced, and this enhancement was completely blocked in the presene of the CD11a (lymphocyte-function associated antigen-1:LFA-1) monoclonal antibody, mNI-58A. Furthermore, production of IL-8 into the culture supernatants from the human PBMCs cultured with β-1.3-1.6 glucan was also significantly augmented. There fingings strongly indicate that the β-1.3-1.6 glucan produced by A, pullulans FO68 sufficiently enhanced some immune responses of human PBMCs. | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11490417 | |||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 6, p. 193-198, 発行日 2005-03-25 |