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Although the pharmacological activity of FK506 depends on its serum concentratio, the serum oncentration of FK506 is widely fluctuated. We hypothesized that the change of FK506 serum concentration is concerned with the portein binding of FK506, because it is well-known that FK506 bind to serum proteins strongly in general. However, the change factors of FK506 serum concentration were not studied. Therefore, the present study was undertaken to investigate the relationship between the change of FK506 serum concentration and serum protein bindgin of FK506, as well as to identify the binding sites of FK506. Binding activities of FK506 to serum, human serum albumin (HAS), α_1-acid glycoprotein (AGP) and human immunoglobulin (IgG) were examined by ultrafiltration method. Serum concentraiton of FK506 was only enevated by the increment of AGP concentration in whole blood system. This means that FK506 transferred from blood cells to serum with increasing AGP oncentration. 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血清中のタクロリムス濃度の変動因子に関する検討 : 血清タンパク結合の観点から
名前 / ファイル | ライセンス | アクション |
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KJ00004191088 (351.6 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||||||||||||||||||||
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公開日 | 2005-03-25 | |||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||
タイトル | 血清中のタクロリムス濃度の変動因子に関する検討 : 血清タンパク結合の観点から | |||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||
タイトル | Study of the Change Factors of Tacrolimus Consentration in Serum : From Viewpoint of Serum Protein Binding | |||||||||||||||||||||||||||
言語 | ||||||||||||||||||||||||||||
言語 | jpn | |||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||
主題 | タクロリムス | |||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||
主題 | タンパク結合 | |||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||
主題 | α_1酸性糖タンパク | |||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||
主題 | ヒト血清アルブミン | |||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||
主題 | tacrolimus | |||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||
主題 | protein binding | |||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||
主題 | α_1-acid glycoprotein | |||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||
主題 | human serum albumin | |||||||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||||||||||||
ID登録 | ||||||||||||||||||||||||||||
ID登録 | 10.15069/00000608 | |||||||||||||||||||||||||||
ID登録タイプ | JaLC | |||||||||||||||||||||||||||
ページ属性 | ||||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||||
内容記述 | P(論文) | |||||||||||||||||||||||||||
記事種別(日) | ||||||||||||||||||||||||||||
薬学部 | ||||||||||||||||||||||||||||
記事種別(英) | ||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||
School of Pharmaceutical Sciences | ||||||||||||||||||||||||||||
著者名(日) |
緒方, 賢次
× 緒方, 賢次
WEKO
1012
× 高村, 徳人
WEKO
1013
× 徳永, 仁
WEKO
1014
× 藤田, 健一× 本屋, 敏郎
WEKO
1016
× 山崎, 啓之× 有森, 和彦 |
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著者名よみ |
オガタ, ケンジ
× オガタ, ケンジ× タカムラ, ノリト× トクナガ, ジン× フジタ, ケンイチ× モトヤ, トシロウ× ヤマサキ, ケイシ× アリモリ, カズヒコ |
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著者名(英) |
OGATA, Kenji
× OGATA, Kenji× TAKAMURA, Norito× TOKUNAGA, Jin× FUJITA, Kenichi× MOTOYA, Toshiro× YAMASAKI, Keishi× ARIMORI, Kazuhiko |
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著者所属(日) | ||||||||||||||||||||||||||||
宮崎大学医学部付属病院薬剤部 | ||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||
九州保健福祉大学薬学部臨床薬学第二講座 | ||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||
九州保健福祉大学薬学部臨床薬学第二講座 | ||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||
埼玉医科大学臨床腫瘍科 | ||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||
九州保健福祉大学薬学部臨床薬学第一講座 | ||||||||||||||||||||||||||||
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宮崎大学医学部付属病院薬剤部 | ||||||||||||||||||||||||||||
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宮崎大学医学部付属病院薬剤部 | ||||||||||||||||||||||||||||
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en | ||||||||||||||||||||||||||||
Department of Pharmacy, Miyazaki Medical College Hospital | ||||||||||||||||||||||||||||
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Second Department of Clinical Pharmacy, School of Phamaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||
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Second Department of Clinical Pharmacy, School of Phamaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||
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Department of Clinical Oncoloty, Saitama Medical School | ||||||||||||||||||||||||||||
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First Department of Clinical Pharmacy, School of Phamaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||
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en | ||||||||||||||||||||||||||||
Department of Pharmacy, Miyazaki Medical College Hospital | ||||||||||||||||||||||||||||
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en | ||||||||||||||||||||||||||||
Department of Pharmacy, Miyazaki Medical College Hospital | ||||||||||||||||||||||||||||
抄録(英) | ||||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||||
内容記述 | Tacrolimus (FK506), which is a potent imuunosuppressive drug, has the excellent effect for prevention of rejection after on organ transu;oanttation. Although the pharmacological activity of FK506 depends on its serum concentratio, the serum oncentration of FK506 is widely fluctuated. We hypothesized that the change of FK506 serum concentration is concerned with the portein binding of FK506, because it is well-known that FK506 bind to serum proteins strongly in general. However, the change factors of FK506 serum concentration were not studied. Therefore, the present study was undertaken to investigate the relationship between the change of FK506 serum concentration and serum protein bindgin of FK506, as well as to identify the binding sites of FK506. Binding activities of FK506 to serum, human serum albumin (HAS), α_1-acid glycoprotein (AGP) and human immunoglobulin (IgG) were examined by ultrafiltration method. Serum concentraiton of FK506 was only enevated by the increment of AGP concentration in whole blood system. This means that FK506 transferred from blood cells to serum with increasing AGP oncentration. In the study of binding sites of FK506, it is obvious that FK506 bind to the overlapping region of acidic and basic drug binding site on AGP molecule. It is important to check AGP serum concentraiton for a dosage plan of FK506. | |||||||||||||||||||||||||||
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収録物識別子タイプ | NCID | |||||||||||||||||||||||||||
収録物識別子 | AA11490417 | |||||||||||||||||||||||||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 6, p. 299-302, 発行日 2005-03-25 |