WEKO3
アイテム
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後根切除による脊髄アストロサイトにおけるβ_2アドレナリン受容体免疫活性の増加
https://doi.org/10.15069/00000707
https://doi.org/10.15069/0000070746b0838b-60de-42a2-8df8-adb78ba39af4
名前 / ファイル | ライセンス | アクション |
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KJ00005059325 (1.7 MB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||||||||||
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公開日 | 2008-03-25 | |||||||||||||||||
タイトル | ||||||||||||||||||
タイトル | 後根切除による脊髄アストロサイトにおけるβ_2アドレナリン受容体免疫活性の増加 | |||||||||||||||||
タイトル | ||||||||||||||||||
言語 | en | |||||||||||||||||
タイトル | Up-regulation of β_2-adrenergic receptor immunoreactivity in astrocytes in the spinal cord after dorsal rhizotomy | |||||||||||||||||
言語 | ||||||||||||||||||
言語 | eng | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | β_2アドレナリン受容体 | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | アストロサイト | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | 後根切除 | |||||||||||||||||
キーワード | ||||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | 脊髄 | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | β_2-adrenergic receptor | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | astrocyte | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | dorsal rhizotomy | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | spinal cord | |||||||||||||||||
資源タイプ | ||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||
ID登録 | ||||||||||||||||||
ID登録 | 10.15069/00000707 | |||||||||||||||||
ID登録タイプ | JaLC | |||||||||||||||||
ページ属性 | ||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||
内容記述 | P(論文) | |||||||||||||||||
著者名(日) |
近藤, 照義
× 近藤, 照義× 中村, 桂一郎× 高村, 徳人
WEKO
1013
× 徳永, 仁
WEKO
1014
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著者名よみ |
コンドウ, テルヨシ
× コンドウ, テルヨシ× ナカムラ, ケイイチロウ× タカムラ, ノリト× トクナガ, ジン |
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著者名(英) |
KONDO, Teruyoshi
× KONDO, Teruyoshi× NAKAMURA, Kei-ichiro× TAKAMURA, Norito× TOKUNAGA, Jin |
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著者所属(日) | ||||||||||||||||||
九州保健福祉大学保健科学部臨床工学科 | ||||||||||||||||||
著者所属(日) | ||||||||||||||||||
久留米大学医学部解剖学講座顕微解剖・生体形成部門 | ||||||||||||||||||
著者所属(日) | ||||||||||||||||||
九州保健福祉大学薬学部臨床薬学第二講座 | ||||||||||||||||||
著者所属(日) | ||||||||||||||||||
九州保健福祉大学薬学部臨床薬学第二講座 | ||||||||||||||||||
著者所属(英) | ||||||||||||||||||
en | ||||||||||||||||||
Department of Clinical Engineering, School of Health Science, Kyushu University of Health and Welfare | ||||||||||||||||||
著者所属(英) | ||||||||||||||||||
en | ||||||||||||||||||
Department of Anatomy, Kurume University School of Medicine | ||||||||||||||||||
著者所属(英) | ||||||||||||||||||
en | ||||||||||||||||||
Second Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||
著者所属(英) | ||||||||||||||||||
en | ||||||||||||||||||
Second Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||
抄録(日) | ||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||
内容記述 | 片側後根切除後1日から7日において、脊髄の後根侵入域及び後索におけるβ_2アドレナリン受容体(β_2AR)の分布様式の変化を免疫組織化学的に検索した。後根切除後2日において、術側のβ_2AR免疫活性は対側に比べて増加し、その増加は切除後7日において顕著であった。β_2AR免疫陽性細胞のほとんどはアストロサイトのマーカーであるGFAPや活性型アストロサイトのマーカーであるネスチンの免疫活性を示した。β_2AR免疫陽性細胞には、時々、増殖マーカーであるKi-67の免疫活性が認められた。β_2AR免疫陽性細胞には、しばしば、FGF-2の免疫活性の増加が認められた。後根切除によるβ_2AR免疫活性の増加及びβ_2AR免疫陽性細胞におけるGFAP、Ki-67、FGF-2の共存関係を考慮すると、脊髄損傷においてβ_2-ARはFGF-2合成を介してアストロサイトの増殖や活性化に関与している可能性が示唆された。 | |||||||||||||||||
抄録(英) | ||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||
内容記述 | Expression pattern of β_2-adrenergic receptor (β_2-AR) in the dorsal entry zone and dorsal funiculus was examined from 2 to 7 days after unilateral transection (rhizotomy) of the C4 and C5 dorsal roots. Rhizotomy induced a marked increase of β_2-AR immunoreactivity (IR) in the regions of the dorsal root entry zone and dorsal funiculus containing the central processes of injured primary sensory neurons. The expression of β_2-AR-IR in regions of the dorsal root entry zone and dorsal funiculus continued to increase with time. β_2-AR-immunoreactive cells co-expressed GFAP-IR and were positive for nestin, which is characteristic of reactive astrocytes. A population of β_2 -AR-immunoreactive cells was labeled with Ki-67, a marker of cell proliferation, indicating that some of them went into cell mitotic state. A subpopulation of β_2-AR-immunoreactive cells also exhibited FGF-2-IR. These findings suggest that β_2-AR may play important roles in astrocytic activation which is associated with the induction of synthesis of growth factor such as FGF-2. | |||||||||||||||||
雑誌書誌ID | ||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||
収録物識別子 | AA11490417 | |||||||||||||||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 9, p. 153-161, 発行日 2008-03 |