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ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討
https://phoenix.repo.nii.ac.jp/records/1307
https://phoenix.repo.nii.ac.jp/records/13075913aeaf-c0f1-4aef-9d75-612cc3129c85
名前 / ファイル | ライセンス | アクション |
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73-77ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討 (786.6 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-07-24 | |||||
タイトル | ||||||
タイトル | ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Investigation of transporter-mediated interaction between cisplatin and silver sulfadiazine in rats | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | シスプラチン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | スルファジアジン銀 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cisplatin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Copper transporter1 (CTR1) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Silver sulfadiazine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
著者名(日) |
小田, 祐一郎
× 小田, 祐一郎× 日髙, 宗明× 鈴木, 彰人 |
|||||
著者名よみ |
おだ, ゆういちろう
× おだ, ゆういちろう |
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著者名(英) |
Oda, Yuichiro
× Oda, Yuichiro |
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著者所属(日) | ||||||
値 | 九州保健福祉大学薬学部 | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cisplatin (CDDP) is a platinum complex and is used for treatment of solid tumors. CDDP administered intravenously is ingested into the cells by copper transporter 1 (CTR1). Silver sulfadiazine (AgSD) is a topical antibiotic that prevent wound infection. Ag is reported to inhibit the mechanism of CTR1. We examined transporter-mediated drug-drug interaction using CDDP and AgSD in rats. The serum concentrations of platinum in blood and in kidney and liver tissues were measured. A blood test was performed to observe the interactive effects of CDDP and AgSD. AgSD pretreatment significantly decreased the concentrations of platinum in blood and in kidney tissue compared to the control. AgSD also diminished the CDDP-induced abnormalities of serum creatinine level but did not affect CTR1 expression. In contrast, no significant change was observed in platinum concentration in liver tissue after AgSD pretreatment. However, the level of alanine aminotransferase increased after administration of CDDP with or without AgSD. These results suggest that CDDP administered intravenously interacts with AgSD applied to region of wound, in association with changing the platinum concentrations in blood and tissue distribution. The interactive effects of CDDP may relate to modulate the function of platinum transferring via CTR1 in the presence of Ag. |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11490417 | |||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 号 18, p. 73-77, 発行日 2017-03-25 |