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Direct detection of diclofenac radical produced by ultraviolet irradiation using electron spin resonance method
https://doi.org/10.15069/00001380
https://doi.org/10.15069/00001380cdb93bfe-d2ce-4f1d-a014-23c1ef04316b
名前 / ファイル | ライセンス | アクション |
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赤崎さとみ学位論文 (429.6 kB)
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⑦審査結果の要旨(赤﨑) (297.8 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-03-13 | |||||
タイトル | ||||||
タイトル | Direct detection of diclofenac radical produced by ultraviolet irradiation using electron spin resonance method | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Direct detection of diclofenac radical produced by ultraviolet irradiation using electron spin resonance method | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/ESR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/diclofenac (DCF) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/nonsteroidal anti-inflammatory drugs (NSAIDs) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/UV irradiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/phototoxicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/DCF radical | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/ESR | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/diclofenac (DCF) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/nonsteroidal anti-inflammatory drugs (NSAIDs) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/UV irradiation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/phototoxicity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | https://ci.nii.ac.jp/keyword/DCF radical | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
ID登録 | ||||||
ID登録 | 10.15069/00001380 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Akazaki, Satomi
× Akazaki, Satomi× Aoki, Ryohei× Sato, Keizo |
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著者(ヨミ) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 7864 | |||||
姓名 | アカザキ, サトミ | |||||
著者(ヨミ) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 7865 | |||||
姓名 | リョウヘイ, アオキ | |||||
著者(ヨミ) | ||||||
識別子Scheme | WEKO | |||||
識別子 | 6695 | |||||
識別子Scheme | CiNii ID | |||||
識別子URI | http://ci.nii.ac.jp/nrid/9000006828334 | |||||
識別子 | 9000006828334 | |||||
姓名 | サトウ, ケイゾウ | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | <p>Diclofenac, a nonsteroidal anti-inflammatory drug, is commonly used as an antipyretic analgesic owing to its strong anti-inflammatory action in clinical treatment. However, diclofenac can cause injury, with gastrointestinal mucosal lesions and skin photosensitivity as the main side effects. In general, photosensitive drugs contain photosensitive chemical sites, and form free radicals under ultraviolet irradiation, leading to phototoxic reactions. Therefore, this study focuses on free radical production in photosensitive reactions of diclofenac. The free radical production mechanism of diclofenac under ultraviolet irradiation, which might result in photo-toxicity, was clarified using a direct electron spin resonance method. When diclofenac was irradiated with ultraviolet light (254 nm), diclofenac radicals were generated depending on the ultraviolet irradiation time and stably present for 30 min at room temperature. Diclofenac radicals were produced by the ultraviolet irradiation system depending on the dose of diclofenac until 2 mM. Therefore, diclofenac radicals might directly or indirectly react with various biomolecules to cause phototoxicity, other side effects, and new diclofenac pharmacology owing to its stability of diclofenac radicals.</p> | |||||
学位名 | ||||||
学位名 | 博士(医療薬学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 九州保健福祉大学 | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2019 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-03-19 | |||||
学位授与番号 | ||||||
学位授与番号 | 博甲第7号 |