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尿毒症物質の血清蛋白結合の特性に関する研究
名前 / ファイル | ライセンス | アクション |
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KJ00004537194 (441.9 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||||||||||||||||||||||||
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公開日 | 2006-03-25 | |||||||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||||||
タイトル | 尿毒症物質の血清蛋白結合の特性に関する研究 | |||||||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
タイトル | Mode of Interaction of Uremic Toxins with Human Serum Albumin and Characterization of Each Binding Site | |||||||||||||||||||||||||||||||
言語 | ||||||||||||||||||||||||||||||||
言語 | jpn | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | 尿毒症物質 | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | ヒト血清アルブミン | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | 静電的相互作用 | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | N-B転移 | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | 結合サイト | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | uremic toxin | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | human serum albumin | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | electrostatic interaction | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | N-B transition | |||||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||||
主題 | binding site | |||||||||||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||||||||||||||||
ID登録 | ||||||||||||||||||||||||||||||||
ID登録 | 10.15069/00000645 | |||||||||||||||||||||||||||||||
ID登録タイプ | JaLC | |||||||||||||||||||||||||||||||
ページ属性 | ||||||||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||||||||
内容記述 | P(論文) | |||||||||||||||||||||||||||||||
著者名(日) |
高村, 徳人
× 高村, 徳人
WEKO
1013
× 徳永, 仁
WEKO
1014
× 緒方, 賢次
WEKO
1012
× 古屋, 弓子× 本屋, 敏郎
WEKO
1016
× 松岡, 俊和
WEKO
1335
× 平井, 正巳× 西尾, 豊隆× 川井, 恵一× 有森, 和彦 |
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著者名よみ |
タカムラ, ノリト
× タカムラ, ノリト× トクナガ, ジン× オガタ, ケンジ× フルヤ, ユミコ× モトヤ, トシロウ× マツオカ, トシカズ× ヒライ, マサミ× ニシオ, トヨタカ× カワイ, ケイイチ× アリモリ, カズヒコ |
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著者名(英) |
TAKAMURA, Norito
× TAKAMURA, Norito× TOKUNAGA, Jin× OGATA, Kenji× FURUYA, Yumiko× MOTOYA, Toshiro× MATSUOKA, Toshikazu× HIRAI, Masami× NISHIO, Toyotaka× KAWAI, Keiichi× ARIMORI, Kazuhiko |
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著者所属(日) | ||||||||||||||||||||||||||||||||
九州保健福祉大学薬学部 | ||||||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||||||
九州保健福祉大学薬学部 | ||||||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||||||
九州保健福祉大学薬学部 | ||||||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||||||
九州保健福祉大学薬学部 | ||||||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||||||
九州保健福祉大学薬学部 | ||||||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||||||
九州保健福祉大学薬学部 | ||||||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||||||
九州保健福祉大学薬学部 | ||||||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||||||
金沢大学大学院医学系研究科保健学専攻 | ||||||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||||||
金沢大学大学院医学系研究科保健学専攻 | ||||||||||||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||||||||||||
宮崎大学医学部附属病院薬剤部 | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
Graduated School of Health Sciences, Faculty of Medicine, Kanazawa University | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
Graduated School of Health Sciences, Faculty of Medicine, Kanazawa University | ||||||||||||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||||||||||||
en | ||||||||||||||||||||||||||||||||
Department of Pharmacy, Miyazaki Medical College Hospital | ||||||||||||||||||||||||||||||||
抄録(英) | ||||||||||||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||||||||||||
内容記述 | The interaction of uremic toxins, indoxyl sulfate (IS), indoleacetic acid (IA) 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), with human serum albumin (HSA) was investigated by ultrafiltration and spectroscopic methods including ultra violet and fluorescence probe method. The primary binding site of IA and IS was designated site II, and the CMPF binding site was site I on the HSA molecule, as indicated by displacement experiments using different site-selective probes. Tyrosine (Tyr) and lysine (Lys) amino acid residues were probably involved in the binding sites of uremic toxins (IS, IA, CMPF) to HSA. Both hydrophobic and electrostatic interactions were found to play a role in the binding of uremic toxins to HSA. Binding of CMPF was sensitive to the N-B transition of HSA. It is suggested that the binding sites consist of a cationic site on the surface of the HSA molecule with a hydrophobic crevice to accommodate the aromatic ring of the uremic toxins. The results obtained in this study will be useful for the exact understanding of the characteristics of protein binding sites of uremic toxins. | |||||||||||||||||||||||||||||||
雑誌書誌ID | ||||||||||||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||||
収録物識別子 | AA11490417 | |||||||||||||||||||||||||||||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 7, p. 211-215, 発行日 2006-03-25 |