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アイテム
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抗Fasモノクローナル抗体処理単球系細胞株(U937)表面上のCD93分子の発現低下
https://doi.org/10.15069/00000668
https://doi.org/10.15069/00000668a6903d69-4646-483a-a5b4-fe0e5b3e37b8
名前 / ファイル | ライセンス | アクション |
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KJ00004702910 (712.6 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-03-25 | |||||
タイトル | ||||||
タイトル | 抗Fasモノクローナル抗体処理単球系細胞株(U937)表面上のCD93分子の発現低下 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Decrease of CD93 expression on the human monocyte-like cell line U937 treated with anti-Fas monoclonal antibody | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抗Fasモノクローナル抗体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | APO2.7 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アポトーシス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD93 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | U937細胞 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | anti-Fas monoclonal antibody | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | APO2.7 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CD93 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | U937 cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15069/00000668 | |||||
ID登録タイプ | JaLC | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
著者名(日) |
池脇, 信直
× 池脇, 信直× 大矢, 和彦 |
|||||
著者名よみ |
イケワキ, ノブナオ
× イケワキ, ノブナオ× オオヤ, カズヒコ |
|||||
著者名(英) |
IKEWAKI, Nobunao
× IKEWAKI, Nobunao× OHYA, Kazuhiko |
|||||
著者所属(日) | ||||||
値 | 九州保健福祉大学保健科学部:高梁学園免疫研究所 | |||||
著者所属(日) | ||||||
値 | 医学生物学研究所伊那研究所 | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Kyushu University of Health and Welfare School of Health Science : Institute of Immunology, Takahashi Educational Institute | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Ina Laboratory, Medical and Biological Laboratories, Co., Ltd. | |||||
抄録(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 抗Fasモノクローナル抗体処理単球系細胞株(U937)表面上の補体(C1q)レセプター(CD93)の発現を我々が開発したCD93モノクローナル抗体(医学生物学研究所で販売)とフローサイトメトリー法を用いて解析した。その結果、抗Fasモノクローナル抗体処理U937細胞はアポトーシスマーカーであるAPO2.7分子の発現を誘導すると共に、細胞表面上のCD93分子の発現を著明に低下させた。また、この発現低下は抗Fasモノクローナル抗体の処理時間に依存していた。以上の結果から、抗Fasモノクローナル抗体処理単球系細胞株(U937)はFas/Fas ligand(Fas/Fas L)システムを介したCD93分子の発現調節を考察する上で非常に有益な情報を提供するものと考えられる。 | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Human CD93, a receptor for complement component 1, subcomponent q (C1qRp), was shown to be selectively expressed by cells of a myeloid lineage, and was originally reported to be involved in the C1q-mediated enhancement of phagocytosis in innate and adaptive immune responses. The modulation of CD93 expression also has been investigated in various cells, in particular, in granulocytes and monocytes. However, its modulation in myeloid cells with apoptotic properties remains poorly understood. In this study, using flow cytometry and two types of CD93 monoclonal antibodies (mAbs), mNI- 11 and X-2, we demonstrated the modulation of CD93 expression on the human monocyte-like cell line (U937) treated with an anti-Fas mAb, a substance for induction of apoptosis through the Fas/Fas ligand (FasL) system. The U937 cells expressed an apoptosis-related molecule, APO 2.7 after treatment with the anti-Fas mAb, and the expression of CD93 defined by mNI-11 or X-2 mAb on these cells was dramatically decreased. Furthermore, the decrease of CD93 expression on the U937 cells treated with anti-Fas mAb occurred in a time-dependent manner. Taken together, theses findings suggest that the decrease of CD93 expression on the U937 cells treated with anti-Fas mAb would be a good model for analyzing immunological responses in myeloid cells with apoptotic properties under C1q and CD93 interactions. | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11490417 | |||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 8, p. 123-131, 発行日 2007-03-25 |