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紫外線(UV-B)がアミノ酸とペプチドの安定性に及ぼす影響
https://doi.org/10.15069/00000744
https://doi.org/10.15069/000007445eda7bf0-a7a4-424d-94df-df6bce1de747
名前 / ファイル | ライセンス | アクション |
---|---|---|
KJ00006191779 (1.7 MB)
|
Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||
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公開日 | 2010-03-01 | |||||||||
タイトル | ||||||||||
タイトル | 紫外線(UV-B)がアミノ酸とペプチドの安定性に及ぼす影響 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Effects of UV-B irradiation on the stability of amino acids and peptides. | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | オゾンホール | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | HPLC | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | 眼 | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | ozone hole | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | HPLC | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | eye | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
資源タイプ | departmental bulletin paper | |||||||||
ID登録 | ||||||||||
ID登録 | 10.15069/00000744 | |||||||||
ID登録タイプ | JaLC | |||||||||
ページ属性 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | P(論文) | |||||||||
著者名(日) |
定金, 豊
× 定金, 豊× 福原, 妙子× 川原, 正博
WEKO
654
× 中込, 和哉 |
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著者名よみ |
サダカネ, ユタカ
× サダカネ, ユタカ× フクハラ, タエコ× カワハラ, マサヒロ× ナカゴミ, カズヤ |
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著者名(英) |
SADAKANE, Yutaka
× SADAKANE, Yutaka× FUKUHARA, Taeko× KAWAHARA, Masahiro× NAKAGOMI, Kazuya |
|||||||||
著者所属(日) | ||||||||||
九州保健福祉大学薬学部薬学科 | ||||||||||
著者所属(日) | ||||||||||
富山大学薬学部 | ||||||||||
著者所属(日) | ||||||||||
九州保健福祉大学薬学部薬学科 | ||||||||||
著者所属(日) | ||||||||||
帝京大学薬学部 | ||||||||||
著者所属(英) | ||||||||||
en | ||||||||||
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||
著者所属(英) | ||||||||||
en | ||||||||||
Faculty of Pharmaceutical Sciences, University of Toyama | ||||||||||
著者所属(英) | ||||||||||
en | ||||||||||
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||
著者所属(英) | ||||||||||
en | ||||||||||
School of Pharmaceutical Sciences, Teikyo University | ||||||||||
抄録(日) | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 紫外線は様々な生体分子に影響を与えることが知られている.今回,我々はUV-B紫外線に対するアミノ酸およびペプチドの安定性を調べた.15種類のペプチドにUV-Bを照射した実験結果から,Trp, His, Met, Phe, Tyrの5種類のアミノ酸を含むペプチドの安定性が低いことがわかった.アミノ酸およびペプチドの安定性は共存するアミノ酸の有無で大きく変化することも明らかになった.Metは共存するアミノ酸があるときのみUV-B照射で減少し,αAクリスタリンを構成するペプチド断片は,タンパク質に紫外線を照射したときに容易に分解した.これらの結果は紫外線を吸収しやすいアミノ酸が他のアミノ酸やペプチド断片の安定性に影響を与えていることを示唆している. | |||||||||
抄録(英) | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | Ultraviolet (UV) light has been reported to influence on various biological components. In this study, we examined the stability of amino acids and peptides against the irradiation of UV-B, the light with 320-400 nm wavelength range. The experiments using 15 types of peptides suggested that the peptides containing five amino acids, Trp, His, Met, Phe, and Tyr were easily reduced by UV-B irradiation. Both stabilities of amino acid and peptide against UV-B irradiation were differed by the presence of coexistent of other amino acids. The amino acid, Met was drastically reduced by UV-B irradiation only in the case of coexistent of other amino acids, and the peptides located in the ��Acrystallin protein also were easily degraded by the irradiation. These results may suggest that amino acids, which easily absorb UV light, had an effect on the stabilities of other amino acid and some peptide fragments. | |||||||||
雑誌書誌ID | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA11490417 | |||||||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 11, p. 147-152, 発行日 2010-03 |