WEKO3
アイテム
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生命現象解明を目指したシアル酸を有する糖鎖の合成
https://doi.org/10.15069/00000931
https://doi.org/10.15069/0000093100371b6e-f204-402a-b40d-3b37104686cf
名前 / ファイル | ライセンス | アクション |
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KJ00009270759 (1.2 MB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||||||||||||||
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公開日 | 2014-03-25 | |||||||||||||||||||||
タイトル | ||||||||||||||||||||||
タイトル | 生命現象解明を目指したシアル酸を有する糖鎖の合成 | |||||||||||||||||||||
タイトル | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
タイトル | Chemical Synthesis of Sialyl Glycosides for Elucidation of Biological Phenomena | |||||||||||||||||||||
言語 | ||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | シアル酸 | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | チオグリコシド | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | 立体選択的合成 | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | 糖鎖合成 | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | シアリルルイスX | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | Sialic acid | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | thioglycoside | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | stereoselective synthesis | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | oligosaccharide synthesis | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | Sialyl Lewis X | |||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||||||
ID登録 | ||||||||||||||||||||||
ID登録 | 10.15069/00000931 | |||||||||||||||||||||
ID登録タイプ | JaLC | |||||||||||||||||||||
ページ属性 | ||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||
内容記述 | P(論文) | |||||||||||||||||||||
著者名(日) |
大塚, 功
× 大塚, 功
WEKO
6641
× 定金, 豊× 渥美, 聡孝
WEKO
6645
× 垣内, 信子
WEKO
6646
|
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著者名よみ |
オオツカ, イサオ
× オオツカ, イサオ× サダカネ, ユタカ× アツミ, トシユキ× カキウチ, ノブコ |
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著者名(英) |
OHTSUKA, Isao
× OHTSUKA, Isao× SADAKANE, Yutaka× ATSUMI, Toshiyuki× KAKIUCHI, Nobuko |
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著者所属(日) | ||||||||||||||||||||||
九州保健福祉大学薬学部薬学科 | ||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||
鈴鹿医療科学大学薬学部 | ||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||
九州保健福祉大学薬学部薬学科 | ||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||
九州保健福祉大学薬学部薬学科 | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
en | ||||||||||||||||||||||
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
en | ||||||||||||||||||||||
Suzuka University of Medical Science | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
en | ||||||||||||||||||||||
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
en | ||||||||||||||||||||||
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||
抄録(日) | ||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||
内容記述 | 糖質に分類されるシアル酸は、様々な生体機能を有していることが知られている。従って、シアル酸を含む糖鎖を化学合成することは、生命現象の解明に寄与するものと考えられる。しかし、シアル酸を糖供与体とする糖鎖合成は困難とされており、近年多くの研究者らによって、新たな処方が開発されてきている。我々は、シアル酸が持つ生体機能の興味を持ち、これを有する糖鎖誘導体 (5) の合成を試みた。 | |||||||||||||||||||||
抄録(英) | ||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||
内容記述 | The sialic acids are now defined as a family of carbohydrates, have very important biological functions. Thus, it considers that oligosaccharides containing them employ elucidation of biological phenomena. However, for synthesis of them glycosylations using donor of sialic acid derivative have been very hard to achieve both high yields and stereoselectivity of them. But recently, Synthesis methods of oligosaccharides containing sialic acids were developed by many researchers. Highly regioand α-stereoselective sialyl glycoside syntheses have been achieved by using, as glycosyl donors, the 2-thioglycoside of Neu5Ac. We were interested in biological functions of oligosaccharide containing sialic acid, and tried to synthesize sialyl lewis X and synthesized trisaccharide derivative which was precursor of sialyl lewis X, α-L-Neu5Ac(2 → 3)β-D-Gal(1 → 4)β-D-GlcNAc-MP. | |||||||||||||||||||||
雑誌書誌ID | ||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||
収録物識別子 | AA11490417 | |||||||||||||||||||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 15, p. 75-81, 発行日 2014-03 |