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ニッケルで処理されたヒト単球系細胞株(U937)におけるCD93分子の動態
https://doi.org/10.15069/00000939
https://doi.org/10.15069/0000093992e1ed32-5280-4096-bcc9-00bd68eefaa4
名前 / ファイル | ライセンス | アクション |
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KJ00009271139 (1.2 MB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||||||||||||
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公開日 | 2014-03-25 | |||||||||||||||||||
タイトル | ||||||||||||||||||||
タイトル | ニッケルで処理されたヒト単球系細胞株(U937)におけるCD93分子の動態 | |||||||||||||||||||
タイトル | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
タイトル | Modulation of CD93 molecule in a human monocyte-like cell line (U937) treated with nickel | |||||||||||||||||||
言語 | ||||||||||||||||||||
言語 | eng | |||||||||||||||||||
キーワード | ||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | CD93 分子 | |||||||||||||||||||
キーワード | ||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | 接触過敏 | |||||||||||||||||||
キーワード | ||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | ニッケル | |||||||||||||||||||
キーワード | ||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | U937 細胞 | |||||||||||||||||||
キーワード | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | CD93 molecule | |||||||||||||||||||
キーワード | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | contact hypersensitivity | |||||||||||||||||||
キーワード | ||||||||||||||||||||
言語 | en | |||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||
主題 | nickel, U937 cells | |||||||||||||||||||
資源タイプ | ||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||||
ID登録 | ||||||||||||||||||||
ID登録 | 10.15069/00000939 | |||||||||||||||||||
ID登録タイプ | JaLC | |||||||||||||||||||
ページ属性 | ||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||
内容記述 | P(論文) | |||||||||||||||||||
著者名(日) |
池脇, 信直
× 池脇, 信直
WEKO
7
× 園田, 徹
WEKO
811
× 右田, 平八
WEKO
6271
|
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著者名よみ |
イケワキ, ノブナオ
× イケワキ, ノブナオ× ソノダ, トオル× ミギタ, ヘイハチ |
|||||||||||||||||||
著者名(英) |
IKEWAKI, Nobunao
× IKEWAKI, Nobunao× SONODA, Tohru× MIGITA, Heihachi |
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著者所属(日) | ||||||||||||||||||||
九州保健福祉大学薬学部動物生命薬科学科臨床免疫学研究室 | ||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||
九州保健福祉大学保健科学部作業療法学科 | ||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||
九州保健福祉大学保健科学部臨床工学科 | ||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||
en | ||||||||||||||||||||
Laboratory of Clinical Immunology, Department of Animal Pharmaceutical Science, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||
en | ||||||||||||||||||||
Department of Occupational Therapy, School of Health Science, Kyushu University of Health and Welfare | ||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||
en | ||||||||||||||||||||
Department of Medical Engineering, Kyushu University of Health and Welfare | ||||||||||||||||||||
抄録(日) | ||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||
内容記述 | ニッケルで処理されたヒト単球系細胞株(U937)におけるCD93 分子の動態を解析した。ニッケル処理はU937 細胞に対してインターロイキン-8(IL-8) の産生を増強しながらアポトーシスを誘導した。また、ニッケル処理によりU937 細胞表面上のCD93 分子(mCD93)の発現は有意に減少し、可溶性CD93 分子(sCD93)の産生は有意に増強した。以上の結果は、CD93 分子の動態が金属(ニッケル)アレルギーの発症メカニズムを解析するための新たなバイオマーカーに成り得ることを示唆している。 | |||||||||||||||||||
抄録(英) | ||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||
内容記述 | In this study, we demonstrated the modulation of CD93 molecules (both membrane-bound and soluble-form) in a human monocyte-like cell line, U937 treated with nickel (Ni2+) to model contact hypersensitivity (CHS), such as metal allergy. Ni2+ induced the apoptosis of the U937 cells accompanied by the enhanced secretion of an inflammatory cytokine, interleukin-8 (IL-8). The percentages and mean fluorescence intensities (MFIs) of membrane-bound CD93 (mCD93) expressed on U937 cells were significantly decreased after treatment with Ni2+ when examined using flow cytometry with a CD93 monoclonal antibody (mAb) (mNI-11), which was established in our laboratories. In contrast, the secretion of soluble-form CD93 (sCD93) from U937 cells increased markedly after treatment with Ni2+. Taken together, these findings suggest that the modulation of CD93 molecules (both mCD93 and sCD93) might serve as a new biomarker for analyzing the inflammatory reaction in CHS induced by Ni2+. | |||||||||||||||||||
雑誌書誌ID | ||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||
収録物識別子 | AA11490417 | |||||||||||||||||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 15, p. 129-137, 発行日 2014-03 |