@article{oai:phoenix.repo.nii.ac.jp:00001306,
 author = {池脇, 信直 and Ikewaki, Nobunao and 園田, 徹 and 東, 和弘 and いけわき, のぶなお and IKEWAKI, Nobunao},
 issue = {18},
 journal = {九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), スイソニアから発生する水素ガス（濃度0.1～0.3％）を含む蒸気混合ガス“XEN”を鼻カニューラで吸入した。吸入後、唾液中の免疫バイオマーカーの動態を酵素抗体法（enzyme immunoassay：EIA）で解析した。その結果、“XEN”吸入15分後、唾液中のインターロイキン-1β（IL-1β）の濃度が吸入前と比較して有意に増加した（P<0.01）。一方、唾液中の可溶性CD44分子（sCD44）は吸入前後で有意な差は認められなかった。以上の結果は、“XEN”が鼻粘膜免疫系を活性化し、生体の免疫力を増強させる作用があることを示唆するものである。, In this preliminary study, we examined the effects of inhalation of a steam mixed gas containing
hydrogen gas on the salivary levels of immune biomarkers, especially interleukin-1????and soluble-form
CD44, in healthy adult volunteers. This gas was generated by the decomposition of superheated steam
using a machine (Suisonia) manufactured by Earth Engineering Co., and was designated as“XEN”in our
laboratory. The salivary levels of interleukin-1????and soluble-form CD44 were measured by enzyme
immunoassay 15 min after the subjects had inhaled “XEN” via a nasal cannula. The results revealed a
significant increase in salivary interleukin-1????levels (P < 0.01), but no significant change (P = 0.093) in
salivary soluble-form CD44 levels at 15 min after“XEN”inhalation, compared to the values measured
before inhalation. These findings indicate that “XEN”rapidly induces salivary interleukin-1????secretion and
that elevated salivary interleukin-1????levels after“XEN”inhalation may reflect the activation of both
natural and acquired immune responses in the living body.},
 pages = {67--72},
 title = {水素ガスを含む蒸気混合ガス吸入後の唾液バイオマーカーの解析},
 year = {2017},
 yomi = {イケワキ, ノブナオ and ソノダ, トオル and アズマ, カズヒロ}
}