@article{oai:phoenix.repo.nii.ac.jp:00001307,
 author = {小田, 祐一郎 and 日髙, 宗明 and 鈴木, 彰人 and おだ, ゆういちろう and Oda, Yuichiro},
 issue = {18},
 journal = {九州保健福祉大学研究紀要, Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), Cisplatin (CDDP) is a platinum complex and is used for treatment of solid tumors. CDDP administered
intravenously is ingested into the cells by copper transporter 1 (CTR1). Silver sulfadiazine (AgSD) is a
topical antibiotic that prevent wound infection. Ag is reported to inhibit the mechanism of CTR1. We
examined transporter-mediated drug-drug interaction using CDDP and AgSD in rats. The serum
concentrations of platinum in blood and in kidney and liver tissues were measured. A blood test was
performed to observe the interactive effects of CDDP and AgSD. AgSD pretreatment significantly
decreased the concentrations of platinum in blood and in kidney tissue compared to the control. AgSD also
diminished the CDDP-induced abnormalities of serum creatinine level but did not affect CTR1 expression.
In contrast, no significant change was observed in platinum concentration in liver tissue after AgSD
pretreatment. However, the level of alanine aminotransferase increased after administration of CDDP
with or without AgSD. These results suggest that CDDP administered intravenously interacts with AgSD
applied to region of wound, in association with changing the platinum concentrations in blood and tissue
distribution. The interactive effects of CDDP may relate to modulate the function of platinum transferring
via CTR1 in the presence of Ag.},
 pages = {73--77},
 title = {ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討},
 year = {2017},
 yomi = {オダ, ユウイチロウ and ヒダカ, ムネアキ and スズキ, アキト}
}