{"created":"2023-06-19T08:50:59.186481+00:00","id":1307,"links":{},"metadata":{"_buckets":{"deposit":"f14cfdf3-cbce-4bf0-902d-cfc07796b73e"},"_deposit":{"created_by":16,"id":"1307","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"1307"},"status":"published"},"_oai":{"id":"oai:phoenix.repo.nii.ac.jp:00001307","sets":["35:104"]},"author_link":["7660","1361","7659","7658","7657"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"18","bibliographicPageEnd":"77","bibliographicPageStart":"73","bibliographic_titles":[{"bibliographic_title":"九州保健福祉大学研究紀要 "},{"bibliographic_title":"Journal of Kyushu University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小田, 祐一郎"},{"creatorName":"オダ, ユウイチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"日髙, 宗明"},{"creatorName":"ヒダカ, ムネアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 彰人"},{"creatorName":"スズキ, アキト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1361","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006251274","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006251274"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"おだ, ゆういちろう"}],"nameIdentifiers":[{"nameIdentifier":"7659","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oda, Yuichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7660","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Cisplatin (CDDP) is a platinum complex and is used for treatment of solid tumors. CDDP administered\nintravenously is ingested into the cells by copper transporter 1 (CTR1). Silver sulfadiazine (AgSD) is a\ntopical antibiotic that prevent wound infection. Ag is reported to inhibit the mechanism of CTR1. We\nexamined transporter-mediated drug-drug interaction using CDDP and AgSD in rats. The serum\nconcentrations of platinum in blood and in kidney and liver tissues were measured. A blood test was\nperformed to observe the interactive effects of CDDP and AgSD. AgSD pretreatment significantly\ndecreased the concentrations of platinum in blood and in kidney tissue compared to the control. AgSD also\ndiminished the CDDP-induced abnormalities of serum creatinine level but did not affect CTR1 expression.\nIn contrast, no significant change was observed in platinum concentration in liver tissue after AgSD\npretreatment. However, the level of alanine aminotransferase increased after administration of CDDP\nwith or without AgSD. These results suggest that CDDP administered intravenously interacts with AgSD\napplied to region of wound, in association with changing the platinum concentrations in blood and tissue\ndistribution. The interactive effects of CDDP may relate to modulate the function of platinum transferring\nvia CTR1 in the presence of Ag.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11490417","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"九州保健福祉大学薬学部"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-07-24"}],"displaytype":"simple","filename":"73-77ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討.pdf","filesize":[{"value":"786.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"73-77ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討","url":"https://phoenix.repo.nii.ac.jp/record/1307/files/73-77ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討.pdf"},"version_id":"e76ee665-9f5e-4abf-833d-1b09185251f0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"シスプラチン","subitem_subject_scheme":"Other"},{"subitem_subject":"スルファジアジン銀","subitem_subject_scheme":"Other"},{"subitem_subject":"Cisplatin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Copper transporter1 (CTR1)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Silver sulfadiazine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討"},{"subitem_title":"Investigation of transporter-mediated interaction between cisplatin and silver sulfadiazine in rats","subitem_title_language":"en"}]},"item_type_id":"1","owner":"16","path":["104"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-24"},"publish_date":"2017-07-24","publish_status":"0","recid":"1307","relation_version_is_last":true,"title":["ラットにおけるシスプラチンとスルファジアジン銀のトランスポーターを介した相互作用の検討"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-06-19T09:02:40.189345+00:00"}