@article{oai:phoenix.repo.nii.ac.jp:00001356,
 author = {池脇, 信直 and Ikewaki, Nobunao and 園田, 徹 and 宮澤, 靖 and 鬼塚, 信 and 近森, 正幸 and いけわき, のぶなお and そのだ, とおる and みやざわ, やすし and おにづか, しん and ちかもり, まさゆき and IKEWAKI, Nobunao and SONODA, Toru and MIYAZAWA, Yasushi and ONIZUKA, Shin and CHIKAMORI, Masayuki},
 issue = {19},
 journal = {九州保健福祉大学研究紀要, Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), 健常人（15名）におけるβ-1,3-1,6 glucan（BG）特異抗体と免疫バイオマーカーの血清レベルを自主開発し
た酵素抗体法（enzyme immunoassay：EIA）を用いて検討した。その結果、健常人血清中にはBG特異
IgG、IgA2およびIgMが恒常的に存在することが分かった。次に、BG特異抗体と免疫バイオマーカーとの
相関性を検討したところ、BG特異IgMは血清総IgMと強い相関（r=0.914、P<0.001）を示した。また、BG
特異IgGは可溶性CD44（sCD44）と有意な相関（r=0.611、P=0.015）を示し、BG特異IgA2はIL-6と有意な
相関（r = 0.588、P = 0.021）を示した。さらに、BG特異IgG、IgA2および IgMとIL-12との相関は有意傾向
（r=0.449、P=0.081；r=0.429、P=0.092； r=0.473、P=0.070）を各々示した。以上の結果は、BG特異IgG、
IgA2および IgM が生体恒常性維持のための免疫応答に密接に関与することを示唆している。, In this clinical study, we examined the serum levels of β-1,3-1,6 glucan (BG)-specific antibodies (IgG,
IgA2 and IgM) and the peripheral blood (PB) levels of immune biomarkers, including the serum total
immunoglobulin (IgG, IgA and IgM), interleukin-6 (IL-6), IL-12 and soluble-form CD44 (sCD44), in 15
normal individuals, using an originally developed enzyme-linked immunoassay (EIA). We found that the
sera of even normal healthy individuals consistently contain BG-specific IgG, IgA2 and IgM, and that the
titers of these antibodies vary widely among individuals. However, the serum titers of BG-specific IgM
were strongly and significantly correlated with the serum total IgM titers (r = 0.914, P < 0.001).
Furthermore, the serum titers of BG-specific IgG were significantly correlated with the serum levels of
sCD44 (r = 0.611, P = 0.015), and the serum titers of BG-specific IgA2 were significantly correlated with
the serum levels of IL-6 (r = 0.588, P = 0.021). In addition, the serum titers of BG-specific IgG, IgA2 and
IgM showed a tendency to be correlated with the serum levels of IL-12 (r = 0.449, P = 0.081; r = 0.429, P
= 0.092; r = 0.473, P = 0.070, respectively). Taken together, these findings show that normal human sera
consistently and naturally contain BG-specific IgG, IgA2 and IgM. Since the titers of these BG-specific
antibodies are correlated with the serum levels of some immune biomarkers, it may be surmised that
they are closely associated with various immunological responses in the living body to maintain a normal
health condition.},
 pages = {87--94},
 title = {健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル},
 year = {2018},
 yomi = {イケワキ, ノブナオ and ソノダ, トオル and ミヤザワ, ヤスシ and オニヅカ, シン and チカモリ, マサユキ}
}