{"created":"2023-06-19T08:51:01.538042+00:00","id":1356,"links":{},"metadata":{"_buckets":{"deposit":"b2a2d9bd-1fa1-4ddf-aabc-350f78ffc07e"},"_deposit":{"created_by":16,"id":"1356","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"1356"},"status":"published"},"_oai":{"id":"oai:phoenix.repo.nii.ac.jp:00001356","sets":["35:114"]},"author_link":["7752","7754","7751","7753","7750","7","11","7758","7760","7756","7755","7757","811","7759","7656"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"19","bibliographicPageEnd":"94","bibliographicPageStart":"87","bibliographic_titles":[{"bibliographic_title":"九州保健福祉大学研究紀要 "},{"bibliographic_title":"Journal of Kyushu University of Health and Welfare","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"池脇, 信直","creatorNameLang":"ja"},{"creatorName":"イケワキ, ノブナオ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikewaki, Nobunao","creatorNameLang":"en"}],"familyNames":[{"familyName":"池脇","familyNameLang":"ja"},{"familyName":"イケワキ","familyNameLang":"ja-Kana"},{"familyName":"Ikewaki","familyNameLang":"en"}],"givenNames":[{"givenName":"信直","givenNameLang":"ja"},{"givenName":"ノブナオ","givenNameLang":"ja-Kana"},{"givenName":"Nobunao","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002154389","nameIdentifierScheme":"CiNii 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のぶなお"}],"nameIdentifiers":[{"nameIdentifier":"7656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"そのだ, とおる"}],"nameIdentifiers":[{"nameIdentifier":"7753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"みやざわ, やすし"}],"nameIdentifiers":[{"nameIdentifier":"7754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"おにづか, しん"}],"nameIdentifiers":[{"nameIdentifier":"7755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ちかもり, まさゆき"}],"nameIdentifiers":[{"nameIdentifier":"7756","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IKEWAKI, Nobunao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"11","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002154389","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002154389"}]},{"creatorNames":[{"creatorName":"SONODA, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIYAZAWA, Yasushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ONIZUKA, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"CHIKAMORI, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7760","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"　健常人（15名）におけるβ-1,3-1,6 glucan（BG）特異抗体と免疫バイオマーカーの血清レベルを自主開発し\nた酵素抗体法（enzyme immunoassay：EIA）を用いて検討した。その結果、健常人血清中にはBG特異\nIgG、IgA2およびIgMが恒常的に存在することが分かった。次に、BG特異抗体と免疫バイオマーカーとの\n相関性を検討したところ、BG特異IgMは血清総IgMと強い相関（r=0.914、P<0.001）を示した。また、BG\n特異IgGは可溶性CD44（sCD44）と有意な相関（r=0.611、P=0.015）を示し、BG特異IgA2はIL-6と有意な\n相関（r = 0.588、P = 0.021）を示した。さらに、BG特異IgG、IgA2および IgMとIL-12との相関は有意傾向\n（r=0.449、P=0.081；r=0.429、P=0.092； r=0.473、P=0.070）を各々示した。以上の結果は、BG特異IgG、\nIgA2および IgM が生体恒常性維持のための免疫応答に密接に関与することを示唆している。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"In this clinical study, we examined the serum levels of β-1,3-1,6 glucan (BG)-specific antibodies (IgG,\nIgA2 and IgM) and the peripheral blood (PB) levels of immune biomarkers, including the serum total\nimmunoglobulin (IgG, IgA and IgM), interleukin-6 (IL-6), IL-12 and soluble-form CD44 (sCD44), in 15\nnormal individuals, using an originally developed enzyme-linked immunoassay (EIA). We found that the\nsera of even normal healthy individuals consistently contain BG-specific IgG, IgA2 and IgM, and that the\ntiters of these antibodies vary widely among individuals. However, the serum titers of BG-specific IgM\nwere strongly and significantly correlated with the serum total IgM titers (r = 0.914, P < 0.001).\nFurthermore, the serum titers of BG-specific IgG were significantly correlated with the serum levels of\nsCD44 (r = 0.611, P = 0.015), and the serum titers of BG-specific IgA2 were significantly correlated with\nthe serum levels of IL-6 (r = 0.588, P = 0.021). In addition, the serum titers of BG-specific IgG, IgA2 and\nIgM showed a tendency to be correlated with the serum levels of IL-12 (r = 0.449, P = 0.081; r = 0.429, P\n= 0.092; r = 0.473, P = 0.070, respectively). Taken together, these findings show that normal human sera\nconsistently and naturally contain BG-specific IgG, IgA2 and IgM. Since the titers of these BG-specific\nantibodies are correlated with the serum levels of some immune biomarkers, it may be surmised that\nthey are closely associated with various immunological responses in the living body to maintain a normal\nhealth condition.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11490417","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Medical Life Science, Kyushu University of Health and Welfare School of Medical Life Science, Institute of Immunology,"},{"subitem_text_language":"en","subitem_text_value":"Department of Occupational Therapy, Kyushu University of Health and Welfare School of Health Science, Institute of Immunology,"},{"subitem_text_language":"en","subitem_text_value":"Department of Orthoptics and Visual Science, Kyushu University of Health and Welfare School of Health Science, Institute of Immunology,"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"九州保健福祉大学生命医科学部生命医科学科・順正学園免疫学研究所"},{"subitem_text_value":"九州保健福祉大学保健科学部作業療法学科・順正学園免疫学研究所"},{"subitem_text_value":"九州保健福祉大学保健科学部視機能療法学科・順正学園免疫学研究所"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-18"}],"displaytype":"detail","filename":"87-94池脇信直ほか.pdf","filesize":[{"value":"744.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Serum levels of β-1,3-1,6 glucan-specific antibodies and immune biomarkers in normal individuals","url":"https://phoenix.repo.nii.ac.jp/record/1356/files/87-94池脇信直ほか.pdf"},"version_id":"5d69f6f3-004b-4ff6-9a41-216b4d472e54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BG 特異抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"},{"subitem_subject":"インターロイキン6","subitem_subject_scheme":"Other"},{"subitem_subject":"インターロイキン12","subitem_subject_scheme":"Other"},{"subitem_subject":"可溶性CD44","subitem_subject_scheme":"Other"},{"subitem_subject":"β-1,3-1,6 glucan-specific antibodies","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biomarker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-12","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sCD44","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル"},{"subitem_title":"Serum levels of β-1,3-1,6 glucan-specific antibodies and immune biomarkers in normal individuals","subitem_title_language":"en"}]},"item_type_id":"1","owner":"16","path":["114"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-18"},"publish_date":"2018-06-18","publish_status":"0","recid":"1356","relation_version_is_last":true,"title":["健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-04-19T06:59:46.123668+00:00"}