@article{oai:phoenix.repo.nii.ac.jp:00001431,
 author = {池脇, 信直 and Ikewaki, Nobunao and 園田, 徹 and 東, 和弘 and いけわき, のぶなお and そのだ, とおる and あずま, かずひろ and IKEWAKI, Nobunao and SONODA, Tohru and AZUMA, Kazuhiro},
 issue = {20},
 journal = {九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), 水素発生装置（スイソニア）から発生する水素ガス（濃度0.1%～ 0.3%）を含む蒸気混合ガスXENを鼻カ
ニューラで吸入した。吸入後、A型およびB型インフルエンザウイルス由来のhemagglutinin（HA）抗原に
対する唾液中IgA2抗体価を自主開発の酵素免疫測定法で解析した。その結果、XEN吸入15分後、A型イ
ンフルエンザウイルス株（A/California/7/2009/H1N1とA/Hong Kong/4801/2014/H3N2）由来のHA抗原
に対する唾液中IgA2抗体価は、吸入前と比較して有意に増加した（P=0.028およびP=0.047）。さらに、XEN
吸入15分後、A型とB型インフルエンザウイルス株（A/Singapore/GP1908/2015/H1N1、A/Hong
Kong/4801/2014/H3N2、B/Texas/2/2013/Victoria system、B/Phuket/1307/2013 /Yamagata system）
由来のHA抗原（ワクチンタイプ）に対する唾液中IgA2抗体価も吸入前と比較して有意に増加した
（P=0.039）。以上の結果から、XENにはHA抗原に対する唾液中IgA2抗体価の増強作用があることがわか
った。, In a previous study, we demonstrated a significant increase in the salivary interleukin-1β (IL-1β) levels
following the administration, via inhalation, of a steam-mixed gas containing hydrogen gas (designated as
XEN) in healthy volunteers. In this study, we examined the salivary titers of immunoglobulin A2 (IgA2)
directed against pathogenic hemagglutinin (HA) antigens derived from influenza virus strains
(hereinafter, shortened to IgA2) after XEN administration by inhalation via a nasal cannula for 15 min in
healthy volunteers. The salivary titers of IgA2 directed against HA antigens were measured using an
originally constructed enzyme immunoassay system. The results indicated significant increases of the
salivary IgA2 directed against the HA antigens derived from the following influenza virus strains after
15 min of XEN inhalation, as compared to the titers recorded prior to the inhalation: A/
California/7/2009/H1N1 (P = 0.028), A/Hong Kong/4801/2014/H3N2 (P = 0.047), vaccine-type containing
HA antigens derived from influenza virus strains, A/Singapore/GP1908/2015/H1N1, A/Hong
Kong/4801/2014/H3N2, B/Texas/2/2013/Victoria system, and B/Phuket/1307/2013 /Yamagata system
(P = 0.039). Taken together, XEN rapidly enhanced the salivary titers of IgA2 directed against HA
antigens derived from influenza viruses, which may imply a role in the protection against influenza virus
infection by activation of humoral immunity (IgA2 action) in the whole body via the nasal mucosal
immune system.},
 pages = {69--74},
 title = {水素ガスを含む蒸気混合ガス吸入後のインフルエンザウイルス由来のhemagglutinin抗原に対する唾液中IgA抗体価の増強},
 year = {2019},
 yomi = {イケワキ, ノブナオ and ソノダ, トオル and アズマ, カズヒロ}
}