{"created":"2023-06-19T08:51:04.994923+00:00","id":1431,"links":{},"metadata":{"_buckets":{"deposit":"6e98725a-6ba3-434d-8f42-ceb50426d73c"},"_deposit":{"created_by":16,"id":"1431","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"1431"},"status":"published"},"_oai":{"id":"oai:phoenix.repo.nii.ac.jp:00001431","sets":["35:124"]},"author_link":["7753","7","823","11","7831","7308","7302","811","7656"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"20","bibliographicPageEnd":"74","bibliographicPageStart":"69","bibliographic_titles":[{"bibliographic_title":"九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"池脇, 信直","creatorNameLang":"ja"},{"creatorName":"イケワキ, ノブナオ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikewaki, Nobunao","creatorNameLang":"en"}],"familyNames":[{"familyName":"池脇","familyNameLang":"ja"},{"familyName":"イケワキ","familyNameLang":"ja-Kana"},{"familyName":"Ikewaki","familyNameLang":"en"}],"givenNames":[{"givenName":"信直","givenNameLang":"ja"},{"givenName":"ノブナオ","givenNameLang":"ja-Kana"},{"givenName":"Nobunao","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002154389","nameIdentifierScheme":"CiNii 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ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004394692"},{"nameIdentifier":"1000070187897","nameIdentifierScheme":"NRID"},{"nameIdentifier":"70187897","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70187897"}]},{"creatorNames":[{"creatorName":"東, 和弘"},{"creatorName":"アズマ, カズヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7302","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000293527533","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000293527533"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"いけわき, のぶなお"}],"nameIdentifiers":[{"nameIdentifier":"7656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"そのだ, とおる"}],"nameIdentifiers":[{"nameIdentifier":"7753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"あずま, かずひろ"}],"nameIdentifiers":[{"nameIdentifier":"7831","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IKEWAKI, Nobunao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"11","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002154389","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002154389"}]},{"creatorNames":[{"creatorName":"SONODA, Tohru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"823","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000004394692","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000004394692"}]},{"creatorNames":[{"creatorName":"AZUMA, Kazuhiro ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7308","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000293527533","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000293527533"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"　水素発生装置（スイソニア）から発生する水素ガス（濃度0.1%～ 0.3%）を含む蒸気混合ガスXENを鼻カ\nニューラで吸入した。吸入後、A型およびB型インフルエンザウイルス由来のhemagglutinin（HA）抗原に\n対する唾液中IgA2抗体価を自主開発の酵素免疫測定法で解析した。その結果、XEN吸入15分後、A型イ\nンフルエンザウイルス株（A/California/7/2009/H1N1とA/Hong Kong/4801/2014/H3N2）由来のHA抗原\nに対する唾液中IgA2抗体価は、吸入前と比較して有意に増加した（P=0.028およびP=0.047）。さらに、XEN\n吸入15分後、A型とB型インフルエンザウイルス株（A/Singapore/GP1908/2015/H1N1、A/Hong\nKong/4801/2014/H3N2、B/Texas/2/2013/Victoria system、B/Phuket/1307/2013 /Yamagata system）\n由来のHA抗原（ワクチンタイプ）に対する唾液中IgA2抗体価も吸入前と比較して有意に増加した\n（P=0.039）。以上の結果から、XENにはHA抗原に対する唾液中IgA2抗体価の増強作用があることがわか\nった。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"In a previous study, we demonstrated a significant increase in the salivary interleukin-1β (IL-1β) levels\nfollowing the administration, via inhalation, of a steam-mixed gas containing hydrogen gas (designated as\nXEN) in healthy volunteers. In this study, we examined the salivary titers of immunoglobulin A2 (IgA2)\ndirected against pathogenic hemagglutinin (HA) antigens derived from influenza virus strains\n(hereinafter, shortened to IgA2) after XEN administration by inhalation via a nasal cannula for 15 min in\nhealthy volunteers. The salivary titers of IgA2 directed against HA antigens were measured using an\noriginally constructed enzyme immunoassay system. The results indicated significant increases of the\nsalivary IgA2 directed against the HA antigens derived from the following influenza virus strains after\n15 min of XEN inhalation, as compared to the titers recorded prior to the inhalation: A/\nCalifornia/7/2009/H1N1 (P = 0.028), A/Hong Kong/4801/2014/H3N2 (P = 0.047), vaccine-type containing\nHA antigens derived from influenza virus strains, A/Singapore/GP1908/2015/H1N1, A/Hong\nKong/4801/2014/H3N2, B/Texas/2/2013/Victoria system, and B/Phuket/1307/2013 /Yamagata system\n(P = 0.039). Taken together, XEN rapidly enhanced the salivary titers of IgA2 directed against HA\nantigens derived from influenza viruses, which may imply a role in the protection against influenza virus\ninfection by activation of humoral immunity (IgA2 action) in the whole body via the nasal mucosal\nimmune system.","subitem_description_type":"Other"}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/00001370","subitem_identifier_reg_type":"JaLC"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11490417","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Medical Life Science, Kyushu University of Health and Welfare School of Medical Life Science, Institute of Immunology, Junsei"},{"subitem_text_language":"en","subitem_text_value":"Azuma Clinic of Internal Medicine"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"九州保健福祉大学生命医科学部生命医科学科・順正学園免疫学研究所"},{"subitem_text_value":"九州保健福祉大学保健科学部作業療法学科・順正学園免疫学研究所"},{"subitem_text_value":"東内科クリニック"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-06-13"}],"displaytype":"detail","filename":"研究紀要20号_69-74池脇信直ほか.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Inhalation of a steam-mixed gas containing hydrogen gas enhances","url":"https://phoenix.repo.nii.ac.jp/record/1431/files/研究紀要20号_69-74池脇信直ほか.pdf"},"version_id":"68b29044-e773-4e8f-bd5e-528fb318e1d1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"酵素免疫測定法","subitem_subject_scheme":"Other"},{"subitem_subject":"ヘマグルチニン","subitem_subject_scheme":"Other"},{"subitem_subject":"唾液IgA2","subitem_subject_scheme":"Other"},{"subitem_subject":"水素ガス含有蒸気混合ガス","subitem_subject_scheme":"Other"},{"subitem_subject":"XEN","subitem_subject_scheme":"Other"},{"subitem_subject":"enzyme immunoassay","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hemagglutinin (HA) antigen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"salivary IgA2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"steam-mixed gas","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"水素ガスを含む蒸気混合ガス吸入後のインフルエンザウイルス由来のhemagglutinin抗原に対する唾液中IgA抗体価の増強","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"水素ガスを含む蒸気混合ガス吸入後のインフルエンザウイルス由来のhemagglutinin抗原に対する唾液中IgA抗体価の増強"},{"subitem_title":"Inhalation of a steam-mixed gas containing hydrogen gas enhances the salivary titers of immunoglobulin A against pathogenic hemagglutinin antigens derived from influenza virus strains in healthy volunteers","subitem_title_language":"en"}]},"item_type_id":"1","owner":"16","path":["124"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-13"},"publish_date":"2019-06-13","publish_status":"0","recid":"1431","relation_version_is_last":true,"title":["水素ガスを含む蒸気混合ガス吸入後のインフルエンザウイルス由来のhemagglutinin抗原に対する唾液中IgA抗体価の増強"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-04-19T06:59:46.348328+00:00"}