{"created":"2023-06-19T08:51:05.505985+00:00","id":1444,"links":{},"metadata":{"_buckets":{"deposit":"a298c9ee-9909-40b4-8907-85eb5f2c63c4"},"_deposit":{"created_by":16,"id":"1444","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"1444"},"status":"published"},"_oai":{"id":"oai:phoenix.repo.nii.ac.jp:00001444","sets":["67:135"]},"author_link":["7865","7861","7862","7863","6695","7864"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-19"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"九州保健福祉大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医療薬学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2019","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"<p>Diclofenac, a nonsteroidal anti-inflammatory drug, is commonly used as an antipyretic analgesic owing to its strong anti-inflammatory action in clinical treatment. However, diclofenac can cause injury, with gastrointestinal mucosal lesions and skin photosensitivity as the main side effects. In general, photosensitive drugs contain photosensitive chemical sites, and form free radicals under ultraviolet irradiation, leading to phototoxic reactions. Therefore, this study focuses on free radical production in photosensitive reactions of diclofenac. The free radical production mechanism of diclofenac under ultraviolet irradiation, which might result in photo-toxicity, was clarified using a direct electron spin resonance method. When diclofenac was irradiated with ultraviolet light (254 nm), diclofenac radicals were generated depending on the ultraviolet irradiation time and stably present for 30 min at room temperature. Diclofenac radicals were produced by the ultraviolet irradiation system depending on the dose of diclofenac until 2 mM. Therefore, diclofenac radicals might directly or indirectly react with various biomolecules to cause phototoxicity, other side effects, and new diclofenac pharmacology owing to its stability of diclofenac radicals.</p>","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"博甲第7号"}]},"item_10006_full_name_22":{"attribute_name":"著者(ﾖﾐ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"7864","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アカザキ, サトミ"}]},{"nameIdentifiers":[{"nameIdentifier":"7865","nameIdentifierScheme":"WEKO"}],"names":[{"name":"リョウヘイ, アオキ"}]},{"nameIdentifiers":[{"nameIdentifier":"6695","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006828334","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006828334"}],"names":[{"name":"サトウ, ケイゾウ"}]}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/00001380","subitem_identifier_reg_type":"JaLC"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akazaki, Satomi"}],"nameIdentifiers":[{"nameIdentifier":"7861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ryohei"}],"nameIdentifiers":[{"nameIdentifier":"7862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Keizo"}],"nameIdentifiers":[{"nameIdentifier":"7863","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-13"}],"displaytype":"detail","filename":"赤崎さとみ.pdf","filesize":[{"value":"429.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"赤崎さとみ学位論文","url":"https://phoenix.repo.nii.ac.jp/record/1444/files/赤崎さとみ.pdf"},"version_id":"2917d41f-f9a2-40a3-9475-57402a90191e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-17"}],"displaytype":"detail","filename":"⑦審査結果の要旨（赤﨑）.pdf","filesize":[{"value":"297.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"⑦審査結果の要旨（赤﨑）","url":"https://phoenix.repo.nii.ac.jp/record/1444/files/⑦審査結果の要旨（赤﨑）.pdf"},"version_id":"106b4423-71ac-4c97-82c0-a0a325a1962d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"https://ci.nii.ac.jp/keyword/ESR","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/diclofenac (DCF)","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/nonsteroidal anti-inflammatory drugs (NSAIDs)","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/UV irradiation","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/phototoxicity","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/DCF radical","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/ESR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/diclofenac (DCF)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/nonsteroidal anti-inflammatory drugs (NSAIDs)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/UV irradiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/phototoxicity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"https://ci.nii.ac.jp/keyword/DCF radical","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Direct detection of diclofenac radical produced by ultraviolet irradiation using electron spin resonance method","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Direct detection of diclofenac radical produced by ultraviolet irradiation using electron spin resonance method"},{"subitem_title":"Direct detection of diclofenac radical produced by ultraviolet irradiation using electron spin resonance method","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"16","path":["135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-13"},"publish_date":"2020-03-13","publish_status":"0","recid":"1444","relation_version_is_last":true,"title":["Direct detection of diclofenac radical produced by ultraviolet irradiation using electron spin resonance method"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-06-19T08:59:37.038622+00:00"}