{"created":"2023-06-19T08:51:05.581385+00:00","id":1445,"links":{},"metadata":{"_buckets":{"deposit":"20ad7797-f306-4d5e-aa06-888d2d25a0a1"},"_deposit":{"created_by":16,"id":"1445","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"1445"},"status":"published"},"_oai":{"id":"oai:phoenix.repo.nii.ac.jp:00001445","sets":["67:135"]},"author_link":["7869","7868","7866","7871","7872","7870","7007","7867"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-19"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"九州保健福祉大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医療薬学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2019","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recruitment of immune cells to adipose tissue is altered dramatically in obesity, which results in chronic inflammation of\nthe adipose tissue that leads to metabolic disorders, such as insulin resistance and type 2 diabetes mellitus. The regulation\nof immune cell infiltration into adipose tissue has prophylactic and therapeutic implications for obesity-related diseases. We\npreviously showed that naringenin, a citrus flavonoid, suppressed macrophage infiltration into adipose tissue by inhibiting\nmonocyte chemoattractant protein-1 (MCP-1) expression in the progression phase to high-fat diet (HFD)-induced obesity.\nIn the current study, we evaluated the effects of naringenin on neutrophil infiltration into adipose tissue, because neutrophils\nalso infiltrate into adipose tissue in the progression phase to obesity. Naringenin suppressed neutrophil infiltration into adipose\ntissue induced by the short-term (2 weeks) feeding of a HFD to mice. Naringenin tended to inhibit the HFD-induced\nexpression of several chemokines, including MCP-1 and MCP-3, in adipose tissue. Naringenin also inhibited MCP-3 expression\nin 3T3-L1 adipocytes and a co-culture of 3T3-L1 adipocytes and RAW264 macrophages. However, naringenin did not\naffect the expression of macrophage inflammatory protein-2 (MIP-2), an important chemokine for neutrophil migration and\nactivation, in macrophages or in a co-culture of adipocytes and macrophages. Our results suggest that naringenin suppresses\nneutrophil infiltration into adipose tissue via the regulation of MCP-3 expression and macrophage infiltration.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"博甲第8号"}]},"item_10006_full_name_22":{"attribute_name":"著者(ﾖﾐ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"7870","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツハコ, リサ"}]},{"nameIdentifiers":[{"nameIdentifier":"7007","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006682222","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006682222"}],"names":[{"name":"ヨシダ, ヒロキ"}]},{"nameIdentifiers":[{"nameIdentifier":"7871","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スギタ, チヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"7872","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クロカワ, マサヒコ"}]}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/00001381","subitem_identifier_reg_type":"JaLC"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"Springer Japan Production Department"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuhako, Rika"}],"nameIdentifiers":[{"nameIdentifier":"7866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"7867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugita, Chihiro"}],"nameIdentifiers":[{"nameIdentifier":"7868","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurokawa, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"7869","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-13"}],"displaytype":"detail","filename":"津波古梨花＿英文論文.pdf","filesize":[{"value":"734.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"津波古学位論文","url":"https://phoenix.repo.nii.ac.jp/record/1445/files/津波古梨花＿英文論文.pdf"},"version_id":"5ba0ec40-2a17-431e-aa91-12899a09eb9f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-13"}],"displaytype":"detail","filename":"学位審査要旨.pdf","filesize":[{"value":"174.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"津波古学位審査要旨","url":"https://phoenix.repo.nii.ac.jp/record/1445/files/学位審査要旨.pdf"},"version_id":"4c1a5eef-cc65-4f43-8355-f6dddcc6431d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Naringenin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Obesity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neutrophil","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MCP-3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MIP-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice"},{"subitem_title":"Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"16","path":["135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-13"},"publish_date":"2020-03-13","publish_status":"0","recid":"1445","relation_version_is_last":true,"title":["Naringenin suppresses neutrophil infiltration into adipose tissue in high-fat diet-induced obese mice"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-06-19T08:59:40.370318+00:00"}