{"created":"2023-06-19T08:51:10.855039+00:00","id":1567,"links":{},"metadata":{"_buckets":{"deposit":"25881ae1-bfd4-48f5-a1d3-dcec6a4ea5c2"},"_deposit":{"created_by":16,"id":"1567","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"1567"},"status":"published"},"_oai":{"id":"oai:phoenix.repo.nii.ac.jp:00001567","sets":["148"]},"author_link":["7940"],"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"№3","bibliographic_titles":[{"bibliographic_title":"Journal of Health and Welfare Investigation"},{"bibliographic_title":"Journal of Health and Welfare Investigation","bibliographic_titleLang":"en"}]}]},"item_3_text_8":{"attribute_name":"出版社","attribute_value_mlt":[{"subitem_text_value":"九州保健福祉大学"}]},"item_3_text_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_text_value":"ISSN 2436-6102"}]},"item_3_textarea_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"造血幹細胞動員薬であるplerixaforは，顆粒球コロニー刺激因子(Granulocyte colony-stimulating factor；G-CSF)と併用し，造血幹細胞の末梢への誘導を促進する目的で使用している．Plerixafor併用症例では末梢血幹細胞採取時に行うフローサイトメーターを用いたCD34陽性細胞測定時に， CD34弱陽性領域に細胞集団を認めることが多く，造血幹細胞以外の細胞の出現が疑われた．そこで，末梢血幹細胞採取患者を G-CSF単独投与群とplerixafor併用投与群に分け比較検討を行ったところ，plerixafor併用投与群ではCD34弱陽性細胞の有意な増加を認め(p<0.01)，CD34弱陽性細胞集団がplerixaforにより末梢へ動員された2型樹状細胞の前駆細胞(progenitor dendritic cell type 2 ; proDC2)であることを明らかにした．Plerixafor使用症例の採取日の決定及び採取した造血幹細胞数の評価には，適切なCD34ゲーティングによるCD34陽性細胞数測定を行う必要があると考えられる．"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-17"}],"displaytype":"detail","filename":"Plerixafor使用患者のCD34弱陽性領域出現細胞に関する検討.pdf","filesize":[{"value":"534.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Plerixafor使用患者のCD34弱陽性領域出現細胞に関する検討","url":"https://phoenix.repo.nii.ac.jp/record/1567/files/Plerixafor使用患者のCD34弱陽性領域出現細胞に関する検討.pdf"},"version_id":"47113c82-2dea-41b4-bfc9-431d5792a4a2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Plerixafor","subitem_subject_scheme":"Other"},{"subitem_subject":"CD34陽性細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"末梢血造血幹細胞採取","subitem_subject_scheme":"Other"},{"subitem_subject":"proDC2","subitem_subject_scheme":"Other"},{"subitem_subject":"plerixafor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CD34+cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peripheral blood stem cell harvest (PBSCH）","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"proDC2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Plerixafor使用患者のCD34弱陽性領域出現細胞に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Plerixafor使用患者のCD34弱陽性領域出現細胞に関する検討"},{"subitem_title":"Investigation of CD34 weakly positive predictive region appearing cells in patients using Plerixafor","subitem_title_language":"en"}]},"item_type_id":"3","owner":"16","path":["148"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-04-17"},"publish_date":"2023-04-17","publish_status":"0","recid":"1567","relation_version_is_last":true,"title":["Plerixafor使用患者のCD34弱陽性領域出現細胞に関する検討"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-06-19T08:56:33.766245+00:00"}