{"created":"2024-04-10T05:37:00.268915+00:00","id":2000084,"links":{},"metadata":{"_buckets":{"deposit":"ce9803bb-deb0-49cf-a820-c8a7aa964982"},"_deposit":{"created_by":16,"id":"2000084","owner":"16","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"2000084"},"status":"published"},"_oai":{"id":"oai:phoenix.repo.nii.ac.jp:02000084","sets":["35:1712127810468"]},"author_link":["1013","1012","7929","7928","7885","1014","7956","7099","7958"],"control_number":"2000084","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-25","bibliographicIssueDateType":"Issued"},"bibliographicNumberOfPages":"7","bibliographicPageEnd":"51","bibliographicPageStart":"45","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"九州保健福祉大学研究紀要","bibliographic_titleLang":"ja"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study systematically evaluated the effects of long- and medium-chain fatty acids (LFAs and MFAs,\nrespectively) on human serum albumin (HSA) sites I and II and α1-acid glycoprotein (AGP) drug binding\nsites using warfarin (site I) and diazepam (site II) as probes.\nFree concentrations of warfarin and diazepam were quantified by UHPLC using ultrafiltration.\nThe results showed that the free fraction of warfarin was lower than that of the control, with increasing\n[LFAs]/[HSA] (the free fraction of diazepam was markedly higher), whereas the free fraction of warfarin\nwas higher than that of the control, with increasing [LFAs]/[AGP] (the free fraction of diazepam was also\nsimilar). In addition, the free fraction of warfarin was slightly higher than that of the control, with\nincreasing [MFAs]/[HSA] (the free fraction of diazepam was markedly higher), and the free fraction of\nwarfarin was slightly higher than that of the control, with increasing [MFAs]/[AGP] (the free fraction of\ndiazepam was also similar).\nThese data suggest that LFAs and MFAs either exert competitive or allosteric inhibition on the binding\nof warfarin and diazepam to HSA and AGP. However, only LFAs may have a cooperative effect on\nwarfarin binding to HSA.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/0002000084","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"九州保健福祉大学","subitem_publisher_language":"ja"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11490417","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13455451","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高村, 徳人","creatorNameLang":"ja"},{"creatorName":"タカムラ, ノリト","creatorNameLang":"ja-Kana"},{"creatorName":"Takamura, Norito","creatorNameLang":"en"}],"familyNames":[{"familyName":"高村","familyNameLang":"ja"},{"familyName":"タカムラ","familyNameLang":"ja-Kana"},{"familyName":"Takamura","familyNameLang":"en"}],"givenNames":[{"givenName":"徳人","givenNameLang":"ja"},{"givenName":"ノリト","givenNameLang":"ja-Kana"},{"givenName":"Norito","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1013","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002747919","nameIdentifierScheme":"CiNii 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Mineo","creatorNameLang":"en"}],"familyNames":[{"familyName":"尾﨑","familyNameLang":"ja"},{"familyName":"オザキ","familyNameLang":"ja-Kana"},{"familyName":"Ozaki","familyNameLang":"en"}],"givenNames":[{"givenName":"峯生","givenNameLang":"ja"},{"givenName":"ミネオ","givenNameLang":"ja-Kana"},{"givenName":"Mineo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"興梠, 靖幸","creatorNameLang":"ja"},{"creatorName":"コウロギ, ヤスユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kourogi, Yasuyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"興梠","familyNameLang":"ja"},{"familyName":"コウロギ","familyNameLang":"ja-Kana"},{"familyName":"Kourogi","familyNameLang":"en"}],"givenNames":[{"givenName":"靖幸","givenNameLang":"ja"},{"givenName":"ヤスユキ","givenNameLang":"ja-Kana"},{"givenName":"Yasuyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永, 仁","creatorNameLang":"ja"},{"creatorName":"トクナガ, ジン","creatorNameLang":"ja-Kana"},{"creatorName":"Tokunaga, Jin","creatorNameLang":"en"}],"familyNames":[{"familyName":"徳永","familyNameLang":"ja"},{"familyName":"トクナガ","familyNameLang":"ja-Kana"},{"familyName":"Tokunaga","familyNameLang":"en"}],"givenNames":[{"givenName":"仁","givenNameLang":"ja"},{"givenName":"ジン","givenNameLang":"ja-Kana"},{"givenName":"Jin","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002747765","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002747765"},{"nameIdentifier":"1000060369171","nameIdentifierScheme":"NRID"},{"nameIdentifier":"60369171","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60369171"}]},{"creatorNames":[{"creatorName":"山口, 裕次","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamaguchi, Yuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"山口","familyNameLang":"ja"},{"familyName":"ヤマグチ","familyNameLang":"ja-Kana"},{"familyName":"Yamaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"裕次","givenNameLang":"ja"},{"givenName":"ユウジ","givenNameLang":"ja-Kana"},{"givenName":"Yuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"園田, 純一郎","creatorNameLang":"ja"},{"creatorName":"ソノダ, ジュンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Sonoda, Junichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"園田","familyNameLang":"ja"},{"familyName":"ソノダ","familyNameLang":"ja-Kana"},{"familyName":"Sonoda","familyNameLang":"en"}],"givenNames":[{"givenName":"純一郎","givenNameLang":"ja"},{"givenName":"ジュンイチロウ","givenNameLang":"ja-Kana"},{"givenName":"Junichiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7099","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000017719664","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000017719664"},{"nameIdentifier":"1000000551293","nameIdentifierScheme":"NRID"},{"nameIdentifier":"00551293","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00551293"}]},{"creatorNames":[{"creatorName":"大崎, 卓","creatorNameLang":"ja"},{"creatorName":"オオサキ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Osaki, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"大崎","familyNameLang":"ja"},{"familyName":"オオサキ","familyNameLang":"ja-Kana"},{"familyName":"Osaki","familyNameLang":"en"}],"givenNames":[{"givenName":"卓","givenNameLang":"ja"},{"givenName":"タカシ","givenNameLang":"ja-Kana"},{"givenName":"Takashi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7958","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-04-10"}],"displaytype":"simple","fileDate":[{"fileDateType":"Updated","fileDateValue":"2024-04-10"}],"filename":"09_ヒト血清アルブミンおよびα1-酸性糖蛋白質の薬物結合サイトに結合するワルファリンとジアゼパムに対する長鎖脂肪酸と中鎖脂肪酸の影響.pdf","filesize":[{"value":"680 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"url":"https://phoenix.repo.nii.ac.jp/record/2000084/files/09_ヒト血清アルブミンおよびα1-酸性糖蛋白質の薬物結合サイトに結合するワルファリンとジアゼパムに対する長鎖脂肪酸と中鎖脂肪酸の影響.pdf"},"version_id":"82637932-2b03-460f-ad2a-aeea83e48177"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ヒト血清アルブミン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"α1- 酸性糖蛋白質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"長鎖脂肪酸","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"中鎖脂肪酸","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物結合サイト","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"human serum albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α1-acid glycoprotein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"long-chain fatty acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"medium-chain fatty acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"drug binding site","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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