@article{oai:phoenix.repo.nii.ac.jp:00000541,
 author = {池脇, 信直 and Ikewaki, Nobunao and 藤井, 昇 and 尾仲, 隆 and 福本, 安甫 and 岩本, 壮太郎 and 玉内, 秀一 and イケワキ, ノブナオ and フジイ, ノボル and オナカ, タカシ and フクモト, ヤスホ and イワモト, ソウタロウ and タマウチ, ヒデカズ and IKEWAKI, Nobunao and FUJII, Noboru and ONAKA, Takashi and FUKUMOTO, Yasuho and IWAMOTO, Soutarou and TAMAUCHI, Hidekazu},
 journal = {九州保健福祉大学研究紀要, Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), 我々は, β-1.3-1.6グルカンが免疫系の調節に密接に関わるインターロイキン8 (IL-8) の産生を誘導することを見出し, 本誌 (3 : 5～9, 2002) に報告した. 今回は, β-1.3-1.6グルカンをマウスに免疫して得られた腹膜腔内浮遊細胞の特徴について検討したところ, 細胞数の増加, 形態変化, さらにはNK活性 (抗腫瘍作用) の上昇が認められた. また, two-color flow cytometry 法からNK活性を獲得した細胞は, Mac-1+NK1.1+の細胞群であることも判明した. この結果は, β-1.3-1.6グルカンがマウス腹膜腔内浮遊細胞に対して免疫能を付与したことを示すものである., We previously succeeded in purifying β-1.3-1.6 glucan produced by the black yeast Aureobasidium pullulans, and reported that this β-1.3-1.6 glucan has unique immunological actions such as inducement of CD11b antigen expression and interleukin-8 (IL-8) production in the human monocyte like cell line, U937. In this study, we investigated some immunological properties of mouse peritoneal cells immunized withβ-1.3-1.6 glucan. The peritoneal cell number immunized with β-1.3-1.6 glucan was significantly enhanced accompanied by morphological changes (spread formation). Furthermore, the peritoneal cells immunized with β-1.3-1.6 glucan acquired natural killer (NK) activity against YAC-1 lymphoma cells. In addition, it was found that double positive cells expressing both Mac-1 (macrophage specific antigen) and NK1.1 (natural killer cell specific antigen) on the peritoneal cells immunized with β-1.3-1.6 glucan were significantly enhanced using two-color flow cytometric analysis. These findings indicate that peritoneal cells immunized with β-1.3-1.6 glucan produced by Aureobasidium pullulans sufficiently acquired immunological activities.},
 pages = {167--172},
 title = {Aureobasidium pullulans の産生するβ-1.3-1.6グルカンを免疫して得られマウス腹膜腔内浮遊細胞の特徴},
 volume = {5},
 year = {2004},
 yomi = {イケワキ, ノブナオ and フジイ, ノボル and オナカ, タカシ and フクモト, ヤスホ and イワモト, ソウタロウ and タマウチ, ヒデカズ}
}