@article{oai:phoenix.repo.nii.ac.jp:00000646,
 author = {池脇, 信直 and Ikewaki, Nobunao and 園田, 徹 and 渋谷, 明隆 and イケワキ, ノブナオ and ソノダ, トオル and シブヤ, アキタカ and IKEWAKI, Nobunao and SONODA, Tohru and SHIBUYA, Akitaka},
 journal = {九州保健福祉大学研究紀要, Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), 肝臓疾患由来末梢血単核球(顆粒球および単球)表面上の補体レセプター(C1qRp)の発現パターンを我々が開発したC1qRpモノクローナル抗体(mNI-11)とフローサイトメトリー法を用いて解析した。その結果、肝硬変、慢性肝炎、肝細胞癌患者由来の顆粒球表面上のC1qRpの発現は、健常人に比べて有意に低下していた(P<0.01)。また、肝硬変患者由来単球表面上のC1qRpの発現も健常人に比べて有意に低下していた(P<0.01)。しかしながら、慢性肝炎、肝細胞癌患者由来の単球表面上のC1qRpの発現は健常人と比べて有意な差は認められなかった(P=0.079およびP=0.534)。以上の結果は、肝臓疾患由来の顆粒球および単球の免疫学的な機能を解析する上で非常に有益な情報を提供するものと考えられる。, Human C1qRp, a receptor for complement component 1, subcomponent q (C1q), was shown to be selectively expressed by cells of myeloid lineage, was originally reported to be involved in the C1q-mediated enhancement of phagocytosis. However, its expression patterns on the granulocytes and monocytes in human peripheral blood mononuclear cells (PBMCs) isolated from patients with various diseases are still not well understood. In this study, focusing on the clinical significance of the expression of this receptor in patients with chronic liver diseases, we demonstrated the expression patterns of C1qRp on the granulocytes and monocytes in PBMCs prepared from patients with some liver diseases, using the C1qRp monoclonal antibody (mAb) mNI-11 and flow cytometry. Analysis of the expression patterns (percentage of expression) of C1qRp on the granulocytes of patients with liver cirrhosis, chronic hepatitis B or C and hepatocellular carcinoma revealed a significantly reduced expression of this receptor in these patients as compared with that in normal healthy donors (P<0.01, P<0.01 and P<0.01, respectively). On the other hand, in relation to the expression of C1qRp on the peripheral blood monocytes in patients with liver diseases, while the expression was significantly decreased in the cells of patients with liver cirrhosis as compared with that of normal healthy donors (P<0.01), the expression levels in the cells of patients with chronic hepatitis B or C and hepatocellular carcinoma were not significantly different from those of normal healthy donors (P=0.079 and P=0.534, respectively). Taken together, these findings indicate that the expression of C1qRp on the granulocytes or monocytes was, in general, decreased in patients with liver diseases, but more significantly so in patients with liver cirrhosis.},
 pages = {183--189},
 title = {肝臓疾患由来末梢血単核球(顆粒球および単球)表面上のClqRpの発現パターン},
 volume = {7},
 year = {2006},
 yomi = {イケワキ, ノブナオ and ソノダ, トオル and シブヤ, アキタカ}
}