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including ultra violet and fluorescence probe method. The primary binding site of IA and IS was designated site II, and the CMPF binding site was site I on the HSA molecule, as indicated by displacement experiments using different site-selective probes. Tyrosine (Tyr) and lysine (Lys) amino acid residues were probably involved in the binding sites of uremic toxins (IS, IA, CMPF) to HSA. Both hydrophobic and electrostatic interactions were found to play a role in the binding of uremic toxins to HSA. Binding of CMPF was sensitive to the N-B transition of HSA. It is suggested that the binding sites consist of a cationic site on the surface of the HSA molecule with a hydrophobic crevice to accommodate the aromatic ring of the uremic toxins. The results obtained in this study will be useful for the exact understanding of the characteristics of protein binding sites of uremic toxins.","subitem_description_type":"Other"}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/00000645","subitem_identifier_reg_type":"JaLC"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11490417","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Graduated School of Health Sciences, Faculty of Medicine, Kanazawa University"},{"subitem_text_language":"en","subitem_text_value":"Graduated School of Health Sciences, Faculty of Medicine, Kanazawa University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmacy, Miyazaki Medical College Hospital"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"九州保健福祉大学薬学部"},{"subitem_text_value":"九州保健福祉大学薬学部"},{"subitem_text_value":"九州保健福祉大学薬学部"},{"subitem_text_value":"九州保健福祉大学薬学部"},{"subitem_text_value":"九州保健福祉大学薬学部"},{"subitem_text_value":"九州保健福祉大学薬学部"},{"subitem_text_value":"九州保健福祉大学薬学部"},{"subitem_text_value":"金沢大学大学院医学系研究科保健学専攻"},{"subitem_text_value":"金沢大学大学院医学系研究科保健学専攻"},{"subitem_text_value":"宮崎大学医学部附属病院薬剤部"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2006-03-25"}],"displaytype":"simple","filename":"KJ00004537194.pdf","filesize":[{"value":"441.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00004537194","url":"https://phoenix.repo.nii.ac.jp/record/651/files/KJ00004537194.pdf"},"version_id":"07db751a-0030-4a82-b00c-3415a6f71688"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"尿毒症物質","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト血清アルブミン","subitem_subject_scheme":"Other"},{"subitem_subject":"静電的相互作用","subitem_subject_scheme":"Other"},{"subitem_subject":"N-B転移","subitem_subject_scheme":"Other"},{"subitem_subject":"結合サイト","subitem_subject_scheme":"Other"},{"subitem_subject":"uremic toxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human serum albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"electrostatic interaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"N-B transition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"binding site","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"尿毒症物質の血清蛋白結合の特性に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"尿毒症物質の血清蛋白結合の特性に関する研究"},{"subitem_title":"Mode of Interaction of Uremic Toxins with Human Serum Albumin and Characterization of Each Binding Site","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["49"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-03-25"},"publish_date":"2006-03-25","publish_status":"0","recid":"651","relation_version_is_last":true,"title":["尿毒症物質の血清蛋白結合の特性に関する研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-04-19T07:10:58.414041+00:00"}