@article{oai:phoenix.repo.nii.ac.jp:00000703,
 author = {池脇, 信直 and Ikewaki, Nobunao and 玉内, 秀一 and 猪子, 英俊 and イケワキ, ノブナオ and タマウチ, ヒデカズ and イノコ, ヒデトシ and IKEWAKI, Nobunao and TAMAUCHI, Hidekazu and INOKO, Hidetoshi},
 journal = {九州保健福祉大学研究紀要, Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), 黒酵母(Aureobasidium plulluns)由来のβ-1,3-1,6 glucanによる単球系細胞株(U937)表面上のCD抗原の動態を各種モノクローナル抗体とフローサイトメトリー法を用いて解析した。その結果、β-1,3-1,6 glucanで培養したU937細胞はCD11b (C3R)、CD54(ICAM-1)、CD93(C1qRp)の発現が有意に増強した(P<0.01)。さらに、β-1,3-1,6 glucanで培養したU937細胞はインターロイキン-8(IL-8)およびアポトーシス関連分子である可溶性Fas分子(sFas)の産生も有意に増強した(P<0.01)。以上の結果から、Aureobasidium plulluns由来のβ-1,3-1,6 glucanはヒトの免疫応答を増強する作用があることがわかった。, We examined the modulation of cell surface antigens in a human monocyte-like cell line, U937, cultured with β-1,3-1,6 glucan, produced by the black yeast Aureobasidium pullulans (A. pullulans), using various monoclonal antibodies (mAbs) to human cluster of differentiation (CD) antigens and flow cytometry. The expressions of CD11b (complement component receptor type-3; CR3), CD54 (intercellular adhesion molecule-1; ICAM-1) and CD93 (receptor for complement component 1, subcomponent q phagocytosis; C1qRp) in the U937 cells cultured with β-1,3-1,6 glucan were significantly (P<0.01) enhanced, compared with those in the control cells (cultured without β-1,3-1,6 glucan), at 48 hrs. In addition, the cells cultured with β-1,3-1,6 glucan significantly (P<0.01) enhanced the production of interleukin-8 (IL-8) and an apoptosis-related molecule, soluble Fas (sFas), into the culture supernatants. Together, these findings strongly indicate that the β-1,3-1,6 glucan derived from A. pullulans has some immunopotentiator effects for some human immune responses.},
 pages = {81--91},
 title = {黒酵母(Aureobasidium plulluns)由来のβ-1,3-1,6 glucanによる単球系細胞株(U937)表面上のCD11b、CD54およびCD93の発現増強},
 volume = {9},
 year = {2008},
 yomi = {イケワキ, ノブナオ and タマウチ, ヒデカズ and イノコ, ヒデトシ}
}