@article{oai:phoenix.repo.nii.ac.jp:00000710,
 author = {岩本, 壮太郎 and 川野, 純一 and 伊吹, 太希 and イワモト, ソウタロウ and カワノ, ジュンイチ and イブキ, タイキ and IWAMOTO, Soutarou and KAWANO, Jun-ichi and IBUKI, Taiki},
 journal = {九州保健福祉大学研究紀要, Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), Reduction in the occurrence of anophthalmos (congenital absence of the eye) in genetically predisposed rats through the use of supplements was demonstrated here. The KUHW rats used in the present experiments were bred in the authors' colonies, and anophthalmos, defined as the absence of one or both eyes, was observed in 53.4% of fourth-generation rats (F4). Among the fifth-generation progeny (F5) born to F4 parents with anophthalmos of both eyes (W-type), anophthalmos occurred in 100 of 195 (51.3%) progeny that were born to F4 parents with anophthalmos of both eyes (W-type) following normal pregnancy, (F5-0). In the experimental group F5-a, anophthalmos occurred in 37 of 71 (52.1%) progeny born to F4 parents that were given a 50% moromi (mash) vinegar solution in place of drinking water from start of gestation to three weeks postparturition. Similarly, no inhibitory effects were observed in progeny in the experimental group F5-b, which were born to F4 parents that were given lutein (6 mg/day) as a supplement in regular drinking water, as indicated by occurrence of anophthalmos in 65 of 121 (53.7%) progeny. Subsequently, progeny born to W-type F5-a and F5-b parents under normal breeding conditions showed markedly decreased occurrence of anophthalmos with 14 of 48 rats (29.2%) and 41 of 148 (27.7%) progeny in groups F6-a and F6-b, respectively, showing anopthalmos. These results suggest that administration of moromi vinegar and lutein improved the constitution of F5 rats and subsequently reduced the occurrence of anophthalmos in F6 rats. Three months after this experiment, anophthalmos was observed in 46 of 69 (group F5-c, 66.7%) progeny born to F4 parents under normal breeding conditions. Subsequently, anophthalmos was observed in 32 of 73 (group F6-c, 43.8%) progeny born to group F5-c W-type parents, indicating that the clear reduction in anopthalmos observed in groups F6-a and F6-b compared to groups F5-a and F5-b was due to moromi vinegar and lutein, and the effects of these supplements were thought to be transient.},
 pages = {135--140},
 title = {無眼球症(anophthalmos)ラットの発症抑制},
 volume = {9},
 year = {2008},
 yomi = {イワモト, ソウタロウ and カワノ, ジュンイチ and イブキ, タイキ}
}