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6-Methoxy-2-naphthyl acetic acid (6MNA) is an active metabolite of an NSAID, nabumetone (Relifen ®). These drugs strongly bind to human serum albumin (HSA) site II, suggesting that protein binding inhibition by 6MNA may promote tissue transfer of FP. We investigated cell membrane permeability of FP in the presence of 6MNA using swine kidney cell line LLC-PK1, in which the upper and lower sides of the cell membrane plate (Transwell ®) were regarded as the tissue and vascular sides, respectively. After adding 6MNA to HSA solution containing FP on the lower side, the FP levels in the upper and lower solutions and cells were measured. FP transfer to the upper side was significantly promoted by the addition of 6MNA with regard to the total and free FP levels. No change in the FP level was noted in cells or wells. It was suggested that concomitant nabumetone may promote transfer of site II binding drugs, such as FP, to the target tissue, increasing the effect even at a low dose.","subitem_description_type":"Other"}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/00000745","subitem_identifier_reg_type":"JaLC"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11490417","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Medical Engineering, College of Health Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medical Science, Kanazawa University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Medical Science, Kanazawa University"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"九州保健福祉大学薬学部薬学科"},{"subitem_text_value":"九州保健福祉大学薬学部薬学科"},{"subitem_text_value":"九州保健福祉大学薬学部薬学科"},{"subitem_text_value":"九州保健福祉大学薬学部薬学科"},{"subitem_text_value":"九州保健福祉大学薬学部薬学科"},{"subitem_text_value":"九州保健福祉大学保健科学部臨床工学科"},{"subitem_text_value":"金沢大学大学院医学研究科"},{"subitem_text_value":"金沢大学大学院医学研究科"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2010-03-01"}],"displaytype":"simple","filename":"KJ00006191879.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00006191879","url":"https://phoenix.repo.nii.ac.jp/record/751/files/KJ00006191879.pdf"},"version_id":"ca5ebf8b-4a63-470f-86ed-a0b78983cc73"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ヒト血清アルブミン","subitem_subject_scheme":"Other"},{"subitem_subject":"蛋白結合","subitem_subject_scheme":"Other"},{"subitem_subject":"サイト2","subitem_subject_scheme":"Other"},{"subitem_subject":"フルルビプロフェン","subitem_subject_scheme":"Other"},{"subitem_subject":"6-メトキシ-2-ナフチル酢酸","subitem_subject_scheme":"Other"},{"subitem_subject":"human serum albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protein binding","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"site 2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"flurbiprofen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"6-methoxy-2-naphthyl acetic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アルブミンサイト2結合阻害薬である6-メトキシー2-ナフチル酢酸によるフチルビプロフェンの蛋白結合阻害に関する基礎的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アルブミンサイト2結合阻害薬である6-メトキシー2-ナフチル酢酸によるフチルビプロフェンの蛋白結合阻害に関する基礎的検討"},{"subitem_title":"Basic study on flurbiprofen protein binding inhibition by an albumin site 2 binding inhibitor, 6-methoxy-2-naphthyl acetic acid.","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["53"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-25"},"publish_date":"2010-03-25","publish_status":"0","recid":"751","relation_version_is_last":true,"title":["アルブミンサイト2結合阻害薬である6-メトキシー2-ナフチル酢酸によるフチルビプロフェンの蛋白結合阻害に関する基礎的検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-04-19T07:10:57.571885+00:00"}