{"created":"2023-06-19T08:50:32.581582+00:00","id":806,"links":{},"metadata":{"_buckets":{"deposit":"2afa6350-4040-4da3-88b3-34855047123e"},"_deposit":{"created_by":16,"id":"806","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"806"},"status":"published"},"_oai":{"id":"oai:phoenix.repo.nii.ac.jp:00000806","sets":["67:79"]},"author_link":["6282","6281","6280"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"二酸化チタンナノ粒子はRS ウイルス感染マウスの肺炎を悪化させる"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-19"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"九州保健福祉大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"37604","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医療薬学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"平成27年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To reveal the effects of TiO2 nanoparticles, used in cosmetics and building materials, on the immune response, a respiratory syncytial virus (RSV) infection mouse model was used. BALB/c mice were exposed once intranasally to TiO2 at 0.5 mg/kg and infected intranasally with RSV five days later. The levels of IFN-γ and chemokine CCL5, representative markers of pneumonia, in the bronchoalveolar lavage fluids of RSV-infected mice had increased significantly in TiO2-exposed mice compared with the control on day 5 post-infection, but not in uninfected mice. While pulmonary viral titers were not affected by TiO2 exposure, an increase in the infiltration of lymphocytes into the alveolar septa in lung tissues was observed. Immunohistochemical analysis revealed aggregation of TiO2 nanoparticles near inflammatory cells in the severely affected region. Thus, a single exposure to TiO2 nanoparticles affected the immune system and exacerbated pneumonia in RSV-infected mice.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"博甲第2号"}]},"item_10006_full_name_22":{"attribute_name":"著者(ﾖﾐ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"6281","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ﾊｼｸﾞﾁ, ｾｲｺ"}]}]},"item_10006_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"6282","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hashiguchi, Seiko"}]}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/00000800","subitem_identifier_reg_type":"JaLC"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"橋口, 誠子"}],"nameIdentifiers":[{"nameIdentifier":"6280","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000249867371","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000249867371"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-06-10"}],"displaytype":"simple","filename":"甲2　博士学位論文内容および審査の要旨.pdf","filesize":[{"value":"98.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"甲2　博士学位論文内容および審査の要旨","url":"https://phoenix.repo.nii.ac.jp/record/806/files/甲2　博士学位論文内容および審査の要旨.pdf"},"version_id":"401a1bc3-9fdf-4fa6-86c0-8588c837aa96"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-06-10"}],"displaytype":"simple","filename":"博甲第2号.pdf","filesize":[{"value":"11.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"博甲第2号","url":"https://phoenix.repo.nii.ac.jp/record/806/files/博甲第2号.pdf"},"version_id":"7f02aed5-39ce-4b8a-94d7-dfa32f16585e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Titanium dioxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nanoparticles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Respiratory syncytial virus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pneumonia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus(RSV)-infected mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus(RSV)-infected mice"},{"subitem_title":"Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus(RSV)-infected mice","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"16","path":["79"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-19"},"publish_date":"2016-05-19","publish_status":"0","recid":"806","relation_version_is_last":true,"title":["Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus(RSV)-infected mice"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-06-19T09:21:05.707723+00:00"}