@article{oai:phoenix.repo.nii.ac.jp:00000825,
 author = {池脇, 信直 and Ikewaki, Nobunao and 園田, 徹 and 佐藤, 薫 and 猪子, 英俊 and イケワキ, ノブナオ and ソノダ, トオル and サトウ, カオル and イノコ, ヒデトシ and IKEWAKI, Nobunao and SONODA, Tohru and SATO, Kaoru and INOKO, Hidetoshi},
 journal = {九州保健福祉大学研究紀要, Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), 臍帯血由来造血幹細胞表面上のCD93の発現を我々が開発したCD93モノクローナル抗体(mNI-11)、既存のCD34抗体、CD45抗体を組み合わせたフローサイトメトリー法で解析した。その結果、臍帯血由来造血幹細胞(CD34+細胞およびCD34+CD45dim+細胞)表面上にはCD93が発現していることが分かった。以上の結果は、CD93が未熟な造血幹細胞の新たな細胞表面マーカーに成り得ると共に、造血幹細胞におけるCD93の免疫学的な機能解析に非常に有益な情報と考えられる。, Human CD93 is a heavily O-glycosylated type I transmembrane protein consisting of unique C-type lectin domains (CTLDs) containing glycoprotein. CD93 is mainly expressed on myeloid cells (monocytes and granulocytes) and endothelial cells. However, the expression patterns of CD93 on various other kinds of cells are not well understood. In this study, we found that CD93 was recognized by a CD93 monoclonal antibody (mAb) (mNI-11) that was established in our laboratories and was expressed on a broad hematopoietic stem cell population (CD34+ cells) from human neonatal umbilical cord blood cells (UCBCs), as shown using a two-color flow cytometric analysis. In addition, the CD93 recognized by mNI-11 was also expressed on a narrow hematopoietic stem cell population(CD34+CD45dim+ cells) in which the non-specific reactivity of CD34 mAb from human neonatal UCBCs was excluded using a three-color flow cytometric analysis. Taken together, these results provide the first evidence concerning the identification of CD93 expression on hematopoietic stem cells. These cell populations (CD34+CD93+ and CD34+CD45dim+CD93+ cells) in human neonatal UCBCs are thought to have an important role in cell biology, transplantation, and immature/mature immune responses.},
 pages = {101--110},
 title = {臍帯血由来造血幹細胞表面上のCD93の発現},
 volume = {13},
 year = {2012},
 yomi = {イケワキ, ノブナオ and ソノダ, トオル and サトウ, カオル and イノコ, ヒデトシ}
}