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からなるリガンドとフェニルジアジリン基を有する分子プローブを開発した。次の問題点として、糖鎖は複雑な構造を有していることから、本分子プローブの合成法の確立が重要であると考えた。我々は、オルソゴナルグリコシル化法により糖鎖部分の合成を目指したが、反応時に糖受容体と糖供与体の脱離基が置換されてしまい、目的化合物が得られなかった。そこでトリクロロアセトイミデート法を用い、糖鎖合成に着手したところ、D- ガラクトース-D- グルコサミンから成る二糖誘導体が得られ分子プローブ(1、2、3) へと導かれた。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Photoaffinity labeling technology is the most efficient method for elucidation of carbohydrate - lectin interactions. However, when carbohydrate probes are synthesized according to conventional this method, the reducing terminus of the sugar is opened to provide an acyclic structure. We were undertaken to solve this problem, and developed new molecular probe containing complete oligosaccharide structure (D-lactose) and phenyldiazirine group for elucidation of carbohydrate - lectin interactions. Next problem, establishment of synthesis method of molecular probe is important subject because carbohydrates are composed of various complex structures. We tried synthesis of oligosaccharides using orthogonal glycosylation strategy. But when glycosyl donor and glycosyl acceptor were coupled by promoter, leaveing group of glycosyl donor (-F group) was substituted to leaving group of glycosyl acceptor (-SPh group). We synthesized Galp-GlcpNAc disaccharide derivatives using glycosyl trichloroacetimidate strategy, and then were obtained 3 types of molecular probes containing ligand and photoreactive group (1, 2, 3).","subitem_description_type":"Other"}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/00000848","subitem_identifier_reg_type":"JaLC"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11490417","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Suzuka University of Medical Science"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Pharmacy Keio University"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Pharmacy Keio University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare "}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"九州保健福祉大学薬学部薬学科"},{"subitem_text_value":"鈴鹿医療科学大学薬学部"},{"subitem_text_value":"慶応義塾大学薬学部"},{"subitem_text_value":"慶応義塾大学薬学部"},{"subitem_text_value":"九州保健福祉大学薬学部薬学科"},{"subitem_text_value":"九州保健福祉大学薬学部薬学科"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-03-01"}],"displaytype":"simple","filename":"KJ00008608119.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00008608119","url":"https://phoenix.repo.nii.ac.jp/record/854/files/KJ00008608119.pdf"},"version_id":"085bcd03-92b3-45df-8ea8-79a6dde0eb16"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"光アフィニティーラベル法","subitem_subject_scheme":"Other"},{"subitem_subject":"糖鎖-レクチン相互作用","subitem_subject_scheme":"Other"},{"subitem_subject":"糖鎖合成","subitem_subject_scheme":"Other"},{"subitem_subject":"オルソゴナルグリコシル化法","subitem_subject_scheme":"Other"},{"subitem_subject":"トリクロロアセトイミデート法","subitem_subject_scheme":"Other"},{"subitem_subject":"分子プローブ","subitem_subject_scheme":"Other"},{"subitem_subject":"Photoaffinity Labeling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"carbohydrate-lectin interaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"orthogonal glycosylation strategy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glycosyl trichloroacetoimidate strategy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"molecular probe","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"トリクロロアセトイミデート法による糖鎖 : レクチン相互作用解明のための光反応基と糖鎖リガンドを有する分子プローブの合成法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"トリクロロアセトイミデート法による糖鎖 : レクチン相互作用解明のための光反応基と糖鎖リガンドを有する分子プローブの合成法の確立"},{"subitem_title":"Establishment of Synthesis Method of Molecular Probe Containing Carbohydrate Ligand and Photoreactive Group for Elucidation of Carbohydrate : Lectin Interactions by Glycosyl Trichloroacetoimidate Strategy","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["56"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-03-25"},"publish_date":"2013-03-25","publish_status":"0","recid":"854","relation_version_is_last":true,"title":["トリクロロアセトイミデート法による糖鎖 : レクチン相互作用解明のための光反応基と糖鎖リガンドを有する分子プローブの合成法の確立"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-04-19T06:58:09.453547+00:00"}