@article{oai:phoenix.repo.nii.ac.jp:00000915,
 author = {徳永, 仁 and Tokunaga, Jin and 高村, 徳人 and Takamura, Norito and 緒方, 賢次 and Ogata, Kenji and 吉田, 裕樹 and 永田, 将司 and 近藤, 照義 and 西尾, 豊隆 and 川井, 恵一 and トクナガ, ジン and タカムラ, ノリト and オガタ, ケンジ and ヨシダ, ヒロキ and ナガタ, マサシ and コンドウ, テルヨシ and ニシオ, トヨタカ and カワイ, ケイイチ and TOKUNAGA, Jin and TAKAMURA, Norito and OGATA, Kenji and YOSHIDA, Hiroki and NAGATA, Masashi and KONDO, Teruyoshi and NISHIO, Toyotaka and KAWAI, Keiichi},
 journal = {九州保健福祉大学研究紀要, Journal of Kyushu University of Health and Welfare},
 month = {Mar},
 note = {P(論文), Drug efficacy depends on the amount of a preparation reaching the target tissue (grade of tissue transfer). In this experiment, we established the normal albumin concentration of a healthy adult (600 μ M) or a low-albumin state indicating marked liver hypofunction (100 μ M) on a cell membrane plate, and evaluated the cell membrane permeability of the probe agents. The cell membrane permeability of phenytoin or valproate depended on the concentration of albumin. Probe agent site-I and -II inhibitors, bucolome and oleic acid, respectively, increased the cell membrane permeability. In the future, the cell membrane permeability of probe agents should be further investigated to estimate the tissue transfer of agents based on various laboratory data (albumin, free fatty acids, uremic toxins, and bilirubin).},
 pages = {193--199},
 title = {細胞膜プレートを使用したサイトプローブ薬物の細胞膜透過性に関する基礎的検討},
 volume = {10},
 year = {2009},
 yomi = {トクナガ, ジン and タカムラ, ノリト and オガタ, ケンジ and ヨシダ, ヒロキ and ナガタ, マサシ and コンドウ, テルヨシ and ニシオ, トヨタカ and カワイ, ケイイチ}
}