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Ni2+ induced the apoptosis of the U937 cells accompanied by the enhanced secretion of an inflammatory cytokine, interleukin-8 (IL-8). The percentages and mean fluorescence intensities (MFIs) of membrane-bound CD93 (mCD93) expressed on U937 cells were significantly decreased after treatment with Ni2+ when examined using flow cytometry with a CD93 monoclonal antibody (mAb) (mNI-11), which was established in our laboratories. In contrast, the secretion of soluble-form CD93 (sCD93) from U937 cells increased markedly after treatment with Ni2+. Taken together, these findings suggest that the modulation of CD93 molecules (both mCD93 and sCD93) might serve as a new biomarker for analyzing the inflammatory reaction in CHS induced by Ni2+.","subitem_description_type":"Other"}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/00000939","subitem_identifier_reg_type":"JaLC"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11490417","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Clinical Immunology, Department of Animal Pharmaceutical Science, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Occupational Therapy, School of Health Science, Kyushu University of Health and Welfare"},{"subitem_text_language":"en","subitem_text_value":"Department of Medical Engineering, Kyushu University of Health and Welfare"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"九州保健福祉大学薬学部動物生命薬科学科臨床免疫学研究室"},{"subitem_text_value":"九州保健福祉大学保健科学部作業療法学科"},{"subitem_text_value":"九州保健福祉大学保健科学部臨床工学科"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-03-01"}],"displaytype":"simple","filename":"KJ00009271139.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00009271139","url":"https://phoenix.repo.nii.ac.jp/record/947/files/KJ00009271139.pdf"},"version_id":"bf9eb516-5771-4878-ba04-74dcfce4d7be"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD93 分子","subitem_subject_scheme":"Other"},{"subitem_subject":"接触過敏","subitem_subject_scheme":"Other"},{"subitem_subject":"ニッケル","subitem_subject_scheme":"Other"},{"subitem_subject":"U937 細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"CD93 molecule","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"contact hypersensitivity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nickel, U937 cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ニッケルで処理されたヒト単球系細胞株(U937)におけるCD93分子の動態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ニッケルで処理されたヒト単球系細胞株(U937)におけるCD93分子の動態"},{"subitem_title":"Modulation of CD93 molecule in a human monocyte-like cell line (U937) treated with nickel","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-25"},"publish_date":"2014-03-25","publish_status":"0","recid":"947","relation_version_is_last":true,"title":["ニッケルで処理されたヒト単球系細胞株(U937)におけるCD93分子の動態"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-04-19T06:59:44.546414+00:00"}