{"created":"2023-06-19T08:50:42.476472+00:00","id":968,"links":{},"metadata":{"_buckets":{"deposit":"0093aca8-ab7b-4cc0-8a9a-a6c83b7cdc09"},"_deposit":{"created_by":3,"id":"968","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"968"},"status":"published"},"_oai":{"id":"oai:phoenix.repo.nii.ac.jp:00000968","sets":["35:75"]},"author_link":["7316","7320","7","7312","9","7315","11","823","7319","7311","811","817"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"128","bibliographicPageStart":"121","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"九州保健福祉大学研究紀要"},{"bibliographic_title":"Journal of Kyushu University of Health and 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Koutarou","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7319","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000293527536","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000293527536"}]},{"creatorNames":[{"creatorName":"OHNO, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7320","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000001411622","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000001411622"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"ヒト血管内皮前駆細胞(Human endothelial progenitor cells :HEPCs)から分泌される可溶性CD93(sCD93)分子の動態を自主開発した抗ヒトCD93 抗体(mNI-11)を用いて解析した。HEPCs は低濃度であるが、sCD93 分子を培養液中に自然分泌していることがわかった。HEPCs をPKC 活性剤であるPMAで処理したところ、sCD93 分子の分泌は有意に増強した(P < 0.01)。また、PMA 処理の初期段階からsCD93 分泌の増強は認められた。次に、PMA 処理HEPCs にPKC 活性阻害剤であるGo6976 を添加したところ、sCD93 分子の分泌は有意に抑制された(P < 0.01)。一方、HEPCs をアクチンフィラメントの脱重合剤(サイトカラシンE)で処理したところ、sCD93 分子の分泌が有意に増強した(P < 0.01)。HEPCs から分泌されるsCD93 分子は、PKC によるリン酸化とアクチンフィラメントの脱重合が密接に関与していることがわかった。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"In this study, we examined the secretion of soluble-form CD93 (sCD93) from human endothelial progenitor cells (HEPCs) expressing cell surface CD93 by enzyme-linked immunoassay (EIA) using CD93 monoclonal antibody (mAb) (mNI-11) established in our laboratories. We found that a small amount of sCD93 was spontaneously secreted into the culture supernatants of HEPCs. Furthermore, significantly (P < 0.01) enhanced secretion of sCD93 was found in the culture supernatants of HEPCs treated with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, which was significantly (P < 0.01) suppressed by treatment of the cells with the protein kinase (PKC) inhibitor Go6976. Interestingly, depolymerization of the actin filaments in the cells by cytochalasin E (CyE) also significantly (P < 0.01) enhanced the sCD93 secretion into the culture supernatants of HEPCs. Taken together, these findings suggest that the sCD93 might serve as a new biomarker for analyzing the biological and immunological functions of HEPCs.","subitem_description_type":"Other"}]},"item_1_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15069/00000960","subitem_identifier_reg_type":"JaLC"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11490417","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Clinical Immunology, Department of Animal Pharmaceutical Science, Kyushu University of Health and Welfare School of Pharmaceutical Sciences"},{"subitem_text_language":"en","subitem_text_value":"Department of Occupational Therapy, Kyushu University of Health and Welfare School of Health Science"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Miyazaki Prefectural Nobeoka Hospital"},{"subitem_text_language":"en","subitem_text_value":"Quality of Life Research Organization, Kyushu University of Health and Welfare"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"九州保健福祉大学薬学部動物生命薬科学科臨床免疫学研究室"},{"subitem_text_value":"九州保健福祉大学保健科学部作業療法学科"},{"subitem_text_value":"宮崎県立延岡病院産婦人科"},{"subitem_text_value":"九州保健福祉大学QOL 研究機構"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-03-01"}],"displaytype":"simple","filename":"KJ00009811239.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"KJ00009811239","url":"https://phoenix.repo.nii.ac.jp/record/968/files/KJ00009811239.pdf"},"version_id":"0d824299-6555-40f1-bb67-bc2ef66d9c63"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"サイトカラシンE","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト血管内皮前駆細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ホルボールミリステートアセテート","subitem_subject_scheme":"Other"},{"subitem_subject":"可溶性CD93 分子","subitem_subject_scheme":"Other"},{"subitem_subject":"cytochalasin E","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human endothelial progenitor cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phorbol 12-myristate 13-acetate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"soluble-form CD93 molecule","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"血管内皮前駆細胞から分泌される可溶性CD93分子","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血管内皮前駆細胞から分泌される可溶性CD93分子"},{"subitem_title":"Secretion of soluble-form CD93 from human endothelial progenitor cells","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["75"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-25"},"publish_date":"2015-03-25","publish_status":"0","recid":"968","relation_version_is_last":true,"title":["血管内皮前駆細胞から分泌される可溶性CD93分子"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-04-19T06:59:44.761895+00:00"}