WEKO3
アイテム
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黒酵母(Aureobasidium plulluns)由来のβ-1,3-1,6 glucanによる単球系細胞株(U937)表面上のCD11b、CD54およびCD93の発現増強
https://doi.org/10.15069/00000697
https://doi.org/10.15069/000006975a27b35e-ee50-4c9a-8dbd-946685daad2e
名前 / ファイル | ライセンス | アクション |
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KJ00005059315 (950.6 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||||
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公開日 | 2008-03-25 | |||||||||||
タイトル | ||||||||||||
タイトル | 黒酵母(Aureobasidium plulluns)由来のβ-1,3-1,6 glucanによる単球系細胞株(U937)表面上のCD11b、CD54およびCD93の発現増強 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Modulation of some cell surface antigens in the monocyte-like cell line U937 in response to β-1,3-1,6 glucan derived from Aureobasidium pullulans | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | β-1,3-1,6グルカン | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | CD抗原 | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | インターロイキン-8(IL-8) | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | 可溶性Fas(sFas) | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | U937細胞 | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | β-1,3-1,6 glucan | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | CD antigens | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | interleukin-8 (IL-8) | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | soluble Fas (sFas) | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | U937 cells | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | departmental bulletin paper | |||||||||||
ID登録 | ||||||||||||
ID登録 | 10.15069/00000697 | |||||||||||
ID登録タイプ | JaLC | |||||||||||
ページ属性 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | P(論文) | |||||||||||
著者名(日) |
池脇, 信直
× 池脇, 信直
WEKO
7
× 玉内, 秀一× 猪子, 英俊 |
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著者名よみ |
イケワキ, ノブナオ
× イケワキ, ノブナオ× タマウチ, ヒデカズ× イノコ, ヒデトシ |
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著者名(英) |
IKEWAKI, Nobunao
× IKEWAKI, Nobunao× TAMAUCHI, Hidekazu× INOKO, Hidetoshi |
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著者所属(日) | ||||||||||||
九州保健福祉大学保健科学部作業療法学科:高梁学園免疫研究所 | ||||||||||||
著者所属(日) | ||||||||||||
北里大学医学部微生物学 | ||||||||||||
著者所属(日) | ||||||||||||
東海大学医学部分子生命学 | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Department of Occupational Therapy, School of Health Science, Kyushu University of Health and Welfare:Institute of Immunology, Takahashi Educational Institute | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Department of Microbiology, Kitasato University School of Medicine | ||||||||||||
著者所属(英) | ||||||||||||
en | ||||||||||||
Department of Molecular Life Science, Tokai University School of Medicine | ||||||||||||
抄録(日) | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 黒酵母(Aureobasidium plulluns)由来のβ-1,3-1,6 glucanによる単球系細胞株(U937)表面上のCD抗原の動態を各種モノクローナル抗体とフローサイトメトリー法を用いて解析した。その結果、β-1,3-1,6 glucanで培養したU937細胞はCD11b (C3R)、CD54(ICAM-1)、CD93(C1qRp)の発現が有意に増強した(P<0.01)。さらに、β-1,3-1,6 glucanで培養したU937細胞はインターロイキン-8(IL-8)およびアポトーシス関連分子である可溶性Fas分子(sFas)の産生も有意に増強した(P<0.01)。以上の結果から、Aureobasidium plulluns由来のβ-1,3-1,6 glucanはヒトの免疫応答を増強する作用があることがわかった。 | |||||||||||
抄録(英) | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | We examined the modulation of cell surface antigens in a human monocyte-like cell line, U937, cultured with β-1,3-1,6 glucan, produced by the black yeast Aureobasidium pullulans (A. pullulans), using various monoclonal antibodies (mAbs) to human cluster of differentiation (CD) antigens and flow cytometry. The expressions of CD11b (complement component receptor type-3; CR3), CD54 (intercellular adhesion molecule-1; ICAM-1) and CD93 (receptor for complement component 1, subcomponent q phagocytosis; C1qRp) in the U937 cells cultured with β-1,3-1,6 glucan were significantly (P<0.01) enhanced, compared with those in the control cells (cultured without β-1,3-1,6 glucan), at 48 hrs. In addition, the cells cultured with β-1,3-1,6 glucan significantly (P<0.01) enhanced the production of interleukin-8 (IL-8) and an apoptosis-related molecule, soluble Fas (sFas), into the culture supernatants. Together, these findings strongly indicate that the β-1,3-1,6 glucan derived from A. pullulans has some immunopotentiator effects for some human immune responses. | |||||||||||
雑誌書誌ID | ||||||||||||
収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AA11490417 | |||||||||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 9, p. 81-91, 発行日 2008-03 |