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ヒト血清アルブミンおよびα1-酸性糖蛋白質の薬物結合サイトに結合するワルファリンとジアゼパムに対する長鎖脂肪酸と中鎖脂肪酸の影響
名前 / ファイル | ライセンス | アクション |
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09_ヒト血清アルブミンおよびα1-酸性糖蛋白質の薬物結合サイトに結合するワルファリンとジアゼパムに対する長鎖脂肪酸と中鎖脂肪酸の影響.pdf (680 KB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||||||||||||||
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公開日 | 2024-04-10 | |||||||||||||||||||||||||||||
タイトル | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
タイトル | ヒト血清アルブミンおよびα1-酸性糖蛋白質の薬物結合サイトに結合するワルファリンとジアゼパムに対する長鎖脂肪酸と中鎖脂肪酸の影響 | |||||||||||||||||||||||||||||
言語 | ||||||||||||||||||||||||||||||
言語 | jpn | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | ヒト血清アルブミン | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | α1- 酸性糖蛋白質 | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | 長鎖脂肪酸 | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | 中鎖脂肪酸 | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | 薬物結合サイト | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | human serum albumin | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | α1-acid glycoprotein | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | long-chain fatty acids | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | medium-chain fatty acids | |||||||||||||||||||||||||||||
キーワード | ||||||||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||||||||||
主題 | drug binding site | |||||||||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||||||||||||||
ID登録 | ||||||||||||||||||||||||||||||
ID登録 | 10.15069/0002000084 | |||||||||||||||||||||||||||||
ID登録タイプ | JaLC | |||||||||||||||||||||||||||||
アクセス権 | ||||||||||||||||||||||||||||||
アクセス権 | open access | |||||||||||||||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||||
著者 |
高村, 徳人
× 高村, 徳人
WEKO
1013
× 緒方, 賢次
WEKO
1012
× 石井, 紗綾× 尾﨑, 峯生× 興梠, 靖幸× 徳永, 仁
WEKO
1014
× 山口, 裕次× 園田, 純一郎
WEKO
7099
× 大崎, 卓 |
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抄録 | ||||||||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||||||||
内容記述 | This study systematically evaluated the effects of long- and medium-chain fatty acids (LFAs and MFAs, respectively) on human serum albumin (HSA) sites I and II and α1-acid glycoprotein (AGP) drug binding sites using warfarin (site I) and diazepam (site II) as probes. Free concentrations of warfarin and diazepam were quantified by UHPLC using ultrafiltration. The results showed that the free fraction of warfarin was lower than that of the control, with increasing [LFAs]/[HSA] (the free fraction of diazepam was markedly higher), whereas the free fraction of warfarin was higher than that of the control, with increasing [LFAs]/[AGP] (the free fraction of diazepam was also similar). In addition, the free fraction of warfarin was slightly higher than that of the control, with increasing [MFAs]/[HSA] (the free fraction of diazepam was markedly higher), and the free fraction of warfarin was slightly higher than that of the control, with increasing [MFAs]/[AGP] (the free fraction of diazepam was also similar). These data suggest that LFAs and MFAs either exert competitive or allosteric inhibition on the binding of warfarin and diazepam to HSA and AGP. However, only LFAs may have a cooperative effect on warfarin binding to HSA. |
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言語 | en | |||||||||||||||||||||||||||||
書誌情報 |
ja : 九州保健福祉大学研究紀要 巻 25, p. 45-51, ページ数 7, 発行日 2024-03-25 |
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出版者 | ||||||||||||||||||||||||||||||
言語 | ja | |||||||||||||||||||||||||||||
出版者 | 九州保健福祉大学 | |||||||||||||||||||||||||||||
ISSN | ||||||||||||||||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||||||||||||||||
収録物識別子 | 13455451 | |||||||||||||||||||||||||||||
書誌レコードID | ||||||||||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||
収録物識別子 | AA11490417 |