WEKO3
アイテム
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トリクロロアセトイミデート法による糖鎖 : レクチン相互作用解明のための光反応基と糖鎖リガンドを有する分子プローブの合成法の確立
https://doi.org/10.15069/00000848
https://doi.org/10.15069/000008486494f00d-b0ab-453c-97c5-8ddbdad67351
名前 / ファイル | ライセンス | アクション |
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KJ00008608119 (1.2 MB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||||||||||||||||||
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公開日 | 2013-03-25 | |||||||||||||||||||||
タイトル | ||||||||||||||||||||||
タイトル | トリクロロアセトイミデート法による糖鎖 : レクチン相互作用解明のための光反応基と糖鎖リガンドを有する分子プローブの合成法の確立 | |||||||||||||||||||||
タイトル | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
タイトル | Establishment of Synthesis Method of Molecular Probe Containing Carbohydrate Ligand and Photoreactive Group for Elucidation of Carbohydrate : Lectin Interactions by Glycosyl Trichloroacetoimidate Strategy | |||||||||||||||||||||
言語 | ||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | 光アフィニティーラベル法 | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | 糖鎖-レクチン相互作用 | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | 糖鎖合成 | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | オルソゴナルグリコシル化法 | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | トリクロロアセトイミデート法 | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | 分子プローブ | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | Photoaffinity Labeling | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | carbohydrate-lectin interaction | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | orthogonal glycosylation strategy | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | Glycosyl trichloroacetoimidate strategy | |||||||||||||||||||||
キーワード | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
主題Scheme | Other | |||||||||||||||||||||
主題 | molecular probe | |||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
資源タイプ | departmental bulletin paper | |||||||||||||||||||||
ID登録 | ||||||||||||||||||||||
ID登録 | 10.15069/00000848 | |||||||||||||||||||||
ID登録タイプ | JaLC | |||||||||||||||||||||
ページ属性 | ||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||
内容記述 | P(論文) | |||||||||||||||||||||
著者名(日) |
大塚, 功
× 大塚, 功
WEKO
6641
× 定金, 豊× 羽田, 紀康× 羽田, 純子× 渥美, 聡孝
WEKO
6645
× 垣内, 信子
WEKO
6646
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著者名よみ |
オオツカ, イサオ
× オオツカ, イサオ× サダカネ, ユタカ× ハダ, ノリヤス× ハダ, ジュンコ× アツミ, トシユキ× カキウチ, ノブコ |
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著者名(英) |
OHTSUKA, Isao
× OHTSUKA, Isao× SADAKANE, Yutaka× HADA, Noriyasu× HADA, Junko× ATSUMI, Toshiyuki× KAKIUCHI, Nobuko |
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著者所属(日) | ||||||||||||||||||||||
九州保健福祉大学薬学部薬学科 | ||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||
鈴鹿医療科学大学薬学部 | ||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||
慶応義塾大学薬学部 | ||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||
慶応義塾大学薬学部 | ||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||
九州保健福祉大学薬学部薬学科 | ||||||||||||||||||||||
著者所属(日) | ||||||||||||||||||||||
九州保健福祉大学薬学部薬学科 | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
en | ||||||||||||||||||||||
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
en | ||||||||||||||||||||||
Suzuka University of Medical Science | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
en | ||||||||||||||||||||||
Faculty of Pharmacy Keio University | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
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Faculty of Pharmacy Keio University | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
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Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||
著者所属(英) | ||||||||||||||||||||||
en | ||||||||||||||||||||||
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare | ||||||||||||||||||||||
抄録(日) | ||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||
内容記述 | 光アフィニティーラベル法は、糖鎖- レクチンの相互関係を明らかにする最も効果的な手法である。従来法では、プローブ合成時に還元末端糖が開環してしまっていたが、我々は、完全な糖鎖構造 (D- ラクトース) からなるリガンドとフェニルジアジリン基を有する分子プローブを開発した。次の問題点として、糖鎖は複雑な構造を有していることから、本分子プローブの合成法の確立が重要であると考えた。我々は、オルソゴナルグリコシル化法により糖鎖部分の合成を目指したが、反応時に糖受容体と糖供与体の脱離基が置換されてしまい、目的化合物が得られなかった。そこでトリクロロアセトイミデート法を用い、糖鎖合成に着手したところ、D- ガラクトース-D- グルコサミンから成る二糖誘導体が得られ分子プローブ(1、2、3) へと導かれた。 | |||||||||||||||||||||
抄録(英) | ||||||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||||||
内容記述 | Photoaffinity labeling technology is the most efficient method for elucidation of carbohydrate - lectin interactions. However, when carbohydrate probes are synthesized according to conventional this method, the reducing terminus of the sugar is opened to provide an acyclic structure. We were undertaken to solve this problem, and developed new molecular probe containing complete oligosaccharide structure (D-lactose) and phenyldiazirine group for elucidation of carbohydrate - lectin interactions. Next problem, establishment of synthesis method of molecular probe is important subject because carbohydrates are composed of various complex structures. We tried synthesis of oligosaccharides using orthogonal glycosylation strategy. But when glycosyl donor and glycosyl acceptor were coupled by promoter, leaveing group of glycosyl donor (-F group) was substituted to leaving group of glycosyl acceptor (-SPh group). We synthesized Galp-GlcpNAc disaccharide derivatives using glycosyl trichloroacetimidate strategy, and then were obtained 3 types of molecular probes containing ligand and photoreactive group (1, 2, 3). | |||||||||||||||||||||
雑誌書誌ID | ||||||||||||||||||||||
収録物識別子タイプ | NCID | |||||||||||||||||||||
収録物識別子 | AA11490417 | |||||||||||||||||||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 巻 14, p. 161-167, 発行日 2013-03 |