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immunoassay:EIA)を用いて検討した。その結果、健常人血清中にはBG特異\nIgG、IgA2およびIgMが恒常的に存在することが分かった。次に、BG特異抗体と免疫バイオマーカーとの\n相関性を検討したところ、BG特異IgMは血清総IgMと強い相関(r=0.914、P\u003c0.001)を示した。また、BG\n特異IgGは可溶性CD44(sCD44)と有意な相関(r=0.611、P=0.015)を示し、BG特異IgA2はIL-6と有意な\n相関(r = 0.588、P = 0.021)を示した。さらに、BG特異IgG、IgA2および IgMとIL-12との相関は有意傾向\n(r=0.449、P=0.081;r=0.429、P=0.092; r=0.473、P=0.070)を各々示した。以上の結果は、BG特異IgG、\nIgA2および IgM が生体恒常性維持のための免疫応答に密接に関与することを示唆している。", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "In this clinical study, we examined the serum levels of β-1,3-1,6 glucan (BG)-specific antibodies (IgG,\nIgA2 and IgM) and the peripheral blood (PB) levels of immune biomarkers, including the serum total\nimmunoglobulin (IgG, IgA and IgM), interleukin-6 (IL-6), IL-12 and soluble-form CD44 (sCD44), in 15\nnormal individuals, using an originally developed enzyme-linked immunoassay (EIA). We found that the\nsera of even normal healthy individuals consistently contain BG-specific IgG, IgA2 and IgM, and that the\ntiters of these antibodies vary widely among individuals. However, the serum titers of BG-specific IgM\nwere strongly and significantly correlated with the serum total IgM titers (r = 0.914, P \u003c 0.001).\nFurthermore, the serum titers of BG-specific IgG were significantly correlated with the serum levels of\nsCD44 (r = 0.611, P = 0.015), and the serum titers of BG-specific IgA2 were significantly correlated with\nthe serum levels of IL-6 (r = 0.588, P = 0.021). In addition, the serum titers of BG-specific IgG, IgA2 and\nIgM showed a tendency to be correlated with the serum levels of IL-12 (r = 0.449, P = 0.081; r = 0.429, P\n= 0.092; r = 0.473, P = 0.070, respectively). Taken together, these findings show that normal human sera\nconsistently and naturally contain BG-specific IgG, IgA2 and IgM. Since the titers of these BG-specific\nantibodies are correlated with the serum levels of some immune biomarkers, it may be surmised that\nthey are closely associated with various immunological responses in the living body to maintain a normal\nhealth condition.", "subitem_description_type": "Other"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11490417", "subitem_source_identifier_type": "NCID"}]}, "item_1_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Medical Life Science, Kyushu University of Health and Welfare School of Medical Life Science, Institute of Immunology,"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Occupational Therapy, Kyushu University of Health and Welfare School of Health Science, Institute of Immunology,"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Orthoptics and Visual Science, Kyushu University of Health and Welfare School of Health Science, Institute of Immunology,"}]}, "item_1_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "九州保健福祉大学生命医科学部生命医科学科・順正学園免疫学研究所"}, {"subitem_text_value": "九州保健福祉大学保健科学部作業療法学科・順正学園免疫学研究所"}, {"subitem_text_value": "九州保健福祉大学保健科学部視機能療法学科・順正学園免疫学研究所"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-06-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "87-94池脇信直ほか.pdf", "filesize": [{"value": "744.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 744600.0, "url": {"label": "Serum levels of β-1,3-1,6 glucan-specific antibodies and immune biomarkers in normal individuals", "url": "https://phoenix.repo.nii.ac.jp/record/1356/files/87-94池脇信直ほか.pdf"}, "version_id": "5d69f6f3-004b-4ff6-9a41-216b4d472e54"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "BG 特異抗体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "バイオマーカー", "subitem_subject_scheme": "Other"}, {"subitem_subject": "インターロイキン6", "subitem_subject_scheme": "Other"}, {"subitem_subject": "インターロイキン12", "subitem_subject_scheme": "Other"}, {"subitem_subject": "可溶性CD44", "subitem_subject_scheme": "Other"}, {"subitem_subject": "β-1,3-1,6 glucan-specific antibodies", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "biomarker", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-6", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-12", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "sCD44", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル"}, {"subitem_title": "Serum levels of β-1,3-1,6 glucan-specific antibodies and immune biomarkers in normal individuals", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "16", "path": ["114"], "permalink_uri": "https://phoenix.repo.nii.ac.jp/records/1356", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-06-18"}, "publish_date": "2018-06-18", "publish_status": "0", "recid": "1356", "relation": {}, "relation_version_is_last": true, "title": ["健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル"], "weko_shared_id": -1}
健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル
https://phoenix.repo.nii.ac.jp/records/1356
https://phoenix.repo.nii.ac.jp/records/13562f5ef187-7a86-46de-adff-918afd44d13e
名前 / ファイル | ライセンス | アクション |
---|---|---|
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-06-18 | |||||
タイトル | ||||||
タイトル | 健常人におけるβ-1,3-1,6 glucan特異抗体と免疫バイオマーカーの血清レベル | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Serum levels of β-1,3-1,6 glucan-specific antibodies and immune biomarkers in normal individuals | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BG 特異抗体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | バイオマーカー | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インターロイキン6 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インターロイキン12 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 可溶性CD44 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | β-1,3-1,6 glucan-specific antibodies | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | biomarker | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | IL-6 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | IL-12 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | sCD44 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
著者名(日) |
池脇, 信直
× 池脇, 信直× 園田, 徹× 宮澤, 靖× 鬼塚, 信× 近森, 正幸 |
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著者名よみ |
いけわき, のぶなお
× いけわき, のぶなお× そのだ, とおる× みやざわ, やすし× おにづか, しん× ちかもり, まさゆき |
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著者名(英) |
IKEWAKI, Nobunao
× IKEWAKI, Nobunao× SONODA, Toru× MIYAZAWA, Yasushi× ONIZUKA, Shin× CHIKAMORI, Masayuki |
|||||
著者所属(日) | ||||||
値 | 九州保健福祉大学生命医科学部生命医科学科・順正学園免疫学研究所 | |||||
著者所属(日) | ||||||
値 | 九州保健福祉大学保健科学部作業療法学科・順正学園免疫学研究所 | |||||
著者所属(日) | ||||||
値 | 九州保健福祉大学保健科学部視機能療法学科・順正学園免疫学研究所 | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Medical Life Science, Kyushu University of Health and Welfare School of Medical Life Science, Institute of Immunology, | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Occupational Therapy, Kyushu University of Health and Welfare School of Health Science, Institute of Immunology, | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Department of Orthoptics and Visual Science, Kyushu University of Health and Welfare School of Health Science, Institute of Immunology, | |||||
抄録(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 健常人(15名)におけるβ-1,3-1,6 glucan(BG)特異抗体と免疫バイオマーカーの血清レベルを自主開発し た酵素抗体法(enzyme immunoassay:EIA)を用いて検討した。その結果、健常人血清中にはBG特異 IgG、IgA2およびIgMが恒常的に存在することが分かった。次に、BG特異抗体と免疫バイオマーカーとの 相関性を検討したところ、BG特異IgMは血清総IgMと強い相関(r=0.914、P<0.001)を示した。また、BG 特異IgGは可溶性CD44(sCD44)と有意な相関(r=0.611、P=0.015)を示し、BG特異IgA2はIL-6と有意な 相関(r = 0.588、P = 0.021)を示した。さらに、BG特異IgG、IgA2および IgMとIL-12との相関は有意傾向 (r=0.449、P=0.081;r=0.429、P=0.092; r=0.473、P=0.070)を各々示した。以上の結果は、BG特異IgG、 IgA2および IgM が生体恒常性維持のための免疫応答に密接に関与することを示唆している。 |
|||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | In this clinical study, we examined the serum levels of β-1,3-1,6 glucan (BG)-specific antibodies (IgG, IgA2 and IgM) and the peripheral blood (PB) levels of immune biomarkers, including the serum total immunoglobulin (IgG, IgA and IgM), interleukin-6 (IL-6), IL-12 and soluble-form CD44 (sCD44), in 15 normal individuals, using an originally developed enzyme-linked immunoassay (EIA). We found that the sera of even normal healthy individuals consistently contain BG-specific IgG, IgA2 and IgM, and that the titers of these antibodies vary widely among individuals. However, the serum titers of BG-specific IgM were strongly and significantly correlated with the serum total IgM titers (r = 0.914, P < 0.001). Furthermore, the serum titers of BG-specific IgG were significantly correlated with the serum levels of sCD44 (r = 0.611, P = 0.015), and the serum titers of BG-specific IgA2 were significantly correlated with the serum levels of IL-6 (r = 0.588, P = 0.021). In addition, the serum titers of BG-specific IgG, IgA2 and IgM showed a tendency to be correlated with the serum levels of IL-12 (r = 0.449, P = 0.081; r = 0.429, P = 0.092; r = 0.473, P = 0.070, respectively). Taken together, these findings show that normal human sera consistently and naturally contain BG-specific IgG, IgA2 and IgM. Since the titers of these BG-specific antibodies are correlated with the serum levels of some immune biomarkers, it may be surmised that they are closely associated with various immunological responses in the living body to maintain a normal health condition. |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11490417 | |||||
書誌情報 |
九州保健福祉大学研究紀要 en : Journal of Kyushu University of Health and Welfare 号 19, p. 87-94, 発行日 2018-03-25 |